Diagnostic accuracy of two-dimensional shear wave elastography and point shear wave elastography in identifying different stages of liver fibrosis in patients with metabolic dysfunction-associated steatotic liver disease: A meta-analysis
To assess the diagnostic accuracy of two-dimensional shear wave elastography (2-D SWE) and point shear wave elastography (pSWE) in detecting liver fibrosis stages in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), a comprehensive search was conducted across four data...
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2025-01-01
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| Series: | Biomolecules & Biomedicine |
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| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/11577 |
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| author | Xiangyi Xu Yiqing Zhang Qiwei Zhu Yuchen Xie Yuanyuan Zhou Bingtian Dong Chaoxue Zhang |
| author_facet | Xiangyi Xu Yiqing Zhang Qiwei Zhu Yuchen Xie Yuanyuan Zhou Bingtian Dong Chaoxue Zhang |
| author_sort | Xiangyi Xu |
| collection | DOAJ |
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To assess the diagnostic accuracy of two-dimensional shear wave elastography (2-D SWE) and point shear wave elastography (pSWE) in detecting liver fibrosis stages in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), a comprehensive search was conducted across four databases up to February 9, 2024. A bivariate random-effects model was used to analyze the diagnostic accuracy of the methods. After screening, thirteen studies involving pSWE included 1,527 patients, while nine studies involving 2-D SWE included 1,088 patients. The areas under the summary receiver operating characteristic (SROC) curves for diagnosing significant fibrosis (F≥2), advanced fibrosis (F≥3), and cirrhosis (F=4) using pSWE and 2-D SWE were as follows: 0.84 (95% CI 0.80-0.87), 0.91 (95% CI 0.88-0.93), and 0.94 (95% CI 0.91-0.95) for pSWE; 0.83 (95% CI 0.79-0.86) 0.85 (95% CI 0.82-0.88), and 0.89 (95% CI 0.86-0.91) for 2-D SWE, respectively. The pooled sensitivity for pSWE and 2-D SWE for stages F≥2, F≥3, and F=4 were 0.71 (95% CI 0.63-0.78), 0.81 (95% CI 0.72-0.88), and 0.81 (95% CI 0.63-0.91) for pSWE, and 0.77 (95% CI 0.68-0.84), 0.80 (95% CI 0.72-0.87), and 0.92 (95% CI 0.75-0.98) for 2-D SWE, respectively. The pooled specificity of pSWE and 2-D SWE for these stages were 0.83 (95% CI 0.76-0.88), 0.87 (95% Cl: 0.81-0.92), and 0.91 (95% CI 0.86-0.94) for pSWE, and 0.76 (95% CI 0.66-0.84), 0.76 (95% CI 0.69-0.82), and 0.83 (95% CI 0.78-0.85) for 2-D SWE, respectively. In conclusion, both 2-D SWE and pSWE demonstrated high diagnostic performance in identifying various stages of liver fibrosis in MASLD patients.
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| format | Article |
| id | doaj-art-449349ed086e48aab0cb35b4c9c3a8fe |
| institution | Kabale University |
| issn | 2831-0896 2831-090X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
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| series | Biomolecules & Biomedicine |
| spelling | doaj-art-449349ed086e48aab0cb35b4c9c3a8fe2025-01-10T16:39:11ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2025-01-0110.17305/bb.2024.11577Diagnostic accuracy of two-dimensional shear wave elastography and point shear wave elastography in identifying different stages of liver fibrosis in patients with metabolic dysfunction-associated steatotic liver disease: A meta-analysisXiangyi Xu0Yiqing Zhang1Qiwei Zhu2Yuchen Xie3Yuanyuan Zhou4Bingtian Dong5https://orcid.org/0000-0003-0268-4445Chaoxue Zhang6Department of Ultrasound, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Ultrasound, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Ultrasound, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Ultrasound, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Ultrasound, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Ultrasound, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Ultrasound, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China To assess the diagnostic accuracy of two-dimensional shear wave elastography (2-D SWE) and point shear wave elastography (pSWE) in detecting liver fibrosis stages in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), a comprehensive search was conducted across four databases up to February 9, 2024. A bivariate random-effects model was used to analyze the diagnostic accuracy of the methods. After screening, thirteen studies involving pSWE included 1,527 patients, while nine studies involving 2-D SWE included 1,088 patients. The areas under the summary receiver operating characteristic (SROC) curves for diagnosing significant fibrosis (F≥2), advanced fibrosis (F≥3), and cirrhosis (F=4) using pSWE and 2-D SWE were as follows: 0.84 (95% CI 0.80-0.87), 0.91 (95% CI 0.88-0.93), and 0.94 (95% CI 0.91-0.95) for pSWE; 0.83 (95% CI 0.79-0.86) 0.85 (95% CI 0.82-0.88), and 0.89 (95% CI 0.86-0.91) for 2-D SWE, respectively. The pooled sensitivity for pSWE and 2-D SWE for stages F≥2, F≥3, and F=4 were 0.71 (95% CI 0.63-0.78), 0.81 (95% CI 0.72-0.88), and 0.81 (95% CI 0.63-0.91) for pSWE, and 0.77 (95% CI 0.68-0.84), 0.80 (95% CI 0.72-0.87), and 0.92 (95% CI 0.75-0.98) for 2-D SWE, respectively. The pooled specificity of pSWE and 2-D SWE for these stages were 0.83 (95% CI 0.76-0.88), 0.87 (95% Cl: 0.81-0.92), and 0.91 (95% CI 0.86-0.94) for pSWE, and 0.76 (95% CI 0.66-0.84), 0.76 (95% CI 0.69-0.82), and 0.83 (95% CI 0.78-0.85) for 2-D SWE, respectively. In conclusion, both 2-D SWE and pSWE demonstrated high diagnostic performance in identifying various stages of liver fibrosis in MASLD patients. https://www.bjbms.org/ojs/index.php/bjbms/article/view/11577Two-dimensional shear wave elastography2-D SWEpoint shear wave elastographypSWEmetabolic dysfunction-associated steatotic liver diseaseMASLD |
| spellingShingle | Xiangyi Xu Yiqing Zhang Qiwei Zhu Yuchen Xie Yuanyuan Zhou Bingtian Dong Chaoxue Zhang Diagnostic accuracy of two-dimensional shear wave elastography and point shear wave elastography in identifying different stages of liver fibrosis in patients with metabolic dysfunction-associated steatotic liver disease: A meta-analysis Biomolecules & Biomedicine Two-dimensional shear wave elastography 2-D SWE point shear wave elastography pSWE metabolic dysfunction-associated steatotic liver disease MASLD |
| title | Diagnostic accuracy of two-dimensional shear wave elastography and point shear wave elastography in identifying different stages of liver fibrosis in patients with metabolic dysfunction-associated steatotic liver disease: A meta-analysis |
| title_full | Diagnostic accuracy of two-dimensional shear wave elastography and point shear wave elastography in identifying different stages of liver fibrosis in patients with metabolic dysfunction-associated steatotic liver disease: A meta-analysis |
| title_fullStr | Diagnostic accuracy of two-dimensional shear wave elastography and point shear wave elastography in identifying different stages of liver fibrosis in patients with metabolic dysfunction-associated steatotic liver disease: A meta-analysis |
| title_full_unstemmed | Diagnostic accuracy of two-dimensional shear wave elastography and point shear wave elastography in identifying different stages of liver fibrosis in patients with metabolic dysfunction-associated steatotic liver disease: A meta-analysis |
| title_short | Diagnostic accuracy of two-dimensional shear wave elastography and point shear wave elastography in identifying different stages of liver fibrosis in patients with metabolic dysfunction-associated steatotic liver disease: A meta-analysis |
| title_sort | diagnostic accuracy of two dimensional shear wave elastography and point shear wave elastography in identifying different stages of liver fibrosis in patients with metabolic dysfunction associated steatotic liver disease a meta analysis |
| topic | Two-dimensional shear wave elastography 2-D SWE point shear wave elastography pSWE metabolic dysfunction-associated steatotic liver disease MASLD |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/11577 |
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