Dry and neovascular “wet” age-related macular degeneration: Upcoming therapies
The age-related macular degeneration (AMD) field is witnessing promising advancements in therapeutic options. Breakthrough drugs such as pegcetacoplan and avacincaptad have been FDA-approved for dry AMD, marking a significant development as there were no treatment options until August 2023. While se...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Indian Journal of Ophthalmology |
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| Online Access: | https://journals.lww.com/10.4103/IJO.IJO_1120_24 |
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| _version_ | 1841556783613607936 |
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| author | Audrey Yan Nasiq Hasan Jay Chhablani |
| author_facet | Audrey Yan Nasiq Hasan Jay Chhablani |
| author_sort | Audrey Yan |
| collection | DOAJ |
| description | The age-related macular degeneration (AMD) field is witnessing promising advancements in therapeutic options. Breakthrough drugs such as pegcetacoplan and avacincaptad have been FDA-approved for dry AMD, marking a significant development as there were no treatment options until August 2023. While several antivascular endothelial growth factor (VEGF) inhibitors have been approved for wet AMD, challenges persist with the need for frequent dosing. New treatments such as gene therapy, cell therapy, WNT pathway agonists, complement inhibitors, and anti-VEGF combination drugs are under development to address these issues. These developments are exciting and hold promise for transforming the field of medicine, offering hope for improved outcomes and enhanced patient care in managing AMD. |
| format | Article |
| id | doaj-art-446f64b683be436698dabc3d36a01b8f |
| institution | Kabale University |
| issn | 0301-4738 1998-3689 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj-art-446f64b683be436698dabc3d36a01b8f2025-01-07T06:28:38ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892025-01-0173Suppl 1S55S6510.4103/IJO.IJO_1120_24Dry and neovascular “wet” age-related macular degeneration: Upcoming therapiesAudrey YanNasiq HasanJay ChhablaniThe age-related macular degeneration (AMD) field is witnessing promising advancements in therapeutic options. Breakthrough drugs such as pegcetacoplan and avacincaptad have been FDA-approved for dry AMD, marking a significant development as there were no treatment options until August 2023. While several antivascular endothelial growth factor (VEGF) inhibitors have been approved for wet AMD, challenges persist with the need for frequent dosing. New treatments such as gene therapy, cell therapy, WNT pathway agonists, complement inhibitors, and anti-VEGF combination drugs are under development to address these issues. These developments are exciting and hold promise for transforming the field of medicine, offering hope for improved outcomes and enhanced patient care in managing AMD.https://journals.lww.com/10.4103/IJO.IJO_1120_24age-related macular degenerationanti-vegf inhibitorsdry amdgene therapyupcoming amd therapywet amd |
| spellingShingle | Audrey Yan Nasiq Hasan Jay Chhablani Dry and neovascular “wet” age-related macular degeneration: Upcoming therapies Indian Journal of Ophthalmology age-related macular degeneration anti-vegf inhibitors dry amd gene therapy upcoming amd therapy wet amd |
| title | Dry and neovascular “wet” age-related macular degeneration: Upcoming therapies |
| title_full | Dry and neovascular “wet” age-related macular degeneration: Upcoming therapies |
| title_fullStr | Dry and neovascular “wet” age-related macular degeneration: Upcoming therapies |
| title_full_unstemmed | Dry and neovascular “wet” age-related macular degeneration: Upcoming therapies |
| title_short | Dry and neovascular “wet” age-related macular degeneration: Upcoming therapies |
| title_sort | dry and neovascular wet age related macular degeneration upcoming therapies |
| topic | age-related macular degeneration anti-vegf inhibitors dry amd gene therapy upcoming amd therapy wet amd |
| url | https://journals.lww.com/10.4103/IJO.IJO_1120_24 |
| work_keys_str_mv | AT audreyyan dryandneovascularwetagerelatedmaculardegenerationupcomingtherapies AT nasiqhasan dryandneovascularwetagerelatedmaculardegenerationupcomingtherapies AT jaychhablani dryandneovascularwetagerelatedmaculardegenerationupcomingtherapies |