Prevalence and risk factors for hyperhomocysteinemia: a population-based cross-sectional study from Hunan, China
Objectives Hyperhomocysteinemia is an independent risk factor for cardiovascular diseases. We aimed to investigate the prevalence and risk factors for hyperhomocysteinemia, especially modifiable lifestyle factors, such as smoking behaviour and dietary factors.Design Population-based cross-sectional...
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BMJ Publishing Group
2021-12-01
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| Online Access: | https://bmjopen.bmj.com/content/11/12/e048575.full |
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| author | Yanhui Dong Yide Yang Jian Li Yuan Lv Yuan Zeng Shuqian Yuan Ming Xie Quanyuan He Xiangli Ye Carl-Friedrich Hocher Bernhard K Kraemer Xiuqin Hong Berthold Hocher |
| author_facet | Yanhui Dong Yide Yang Jian Li Yuan Lv Yuan Zeng Shuqian Yuan Ming Xie Quanyuan He Xiangli Ye Carl-Friedrich Hocher Bernhard K Kraemer Xiuqin Hong Berthold Hocher |
| author_sort | Yanhui Dong |
| collection | DOAJ |
| description | Objectives Hyperhomocysteinemia is an independent risk factor for cardiovascular diseases. We aimed to investigate the prevalence and risk factors for hyperhomocysteinemia, especially modifiable lifestyle factors, such as smoking behaviour and dietary factors.Design Population-based cross-sectional study.Setting Hunan Province, ChinaParticipants A total of 4012 participants completed the study, between July 2013 and March 2014. The median age is 55 (interquartile range: 45–63) years, with 1644 males (41%) and 2368 females (59%).Main outcome measures Homocysteine level were measured by the microplate enzyme immunoassay method. Hyperthomocysteinemia was defined as ≥15 µmol/L. Questionnaire was used to investigate potential risk factors of hyperhomocysteinemia. Crude odd ratio (OR) or adjusted OR with 95% CI were determined by using univariable or multivariable logistic regression models.Results The prevalence of hyperhomocysteinemia is 35.4% (45.4% vs 28.5% for men, women, respectively). One-year increase in age is significantly associated with 2% higher risk of hyperhomocysteinemia (OR=1.02, 95% CI: 1.01 to 1.03). One unit increase of BMI is associated with 5% higher risk of hyperhomocysteinemia (OR=1.05, 95% CI: 1.03 to 1.07). Compared with the non-smoker, smoking participants have a 24% higher risk of hyperhomocysteinemia (OR=1.24, 95% CI: 1.006 to 1.53), while the risk for those quitting smoking are not significantly different (OR=1.14, 95% CI: 0.85 to 1.54). compared with those consuming fruit and vegetable at least once every day, those consuming less than once every day had a significantly higher risk of hyperhomocysteinemia (OR=1.29, 95% CI:1.11 to 1.50). In addition, we found there were significant sex interaction with education level or alcohol drinking on the risk of hyperhomocysteinemia (pinteraction <0.05).Conclusions Higher BMI and older age are potential risk factors for hyperhomocysteinemia. Current smoking but not quitting smoking is associated with higher risk of hyperhomocysteinemia. Fruit and vegetable consumption may have protective effect against hyperhomocysteinemia. Alcohol consumption or education level might interact to influence the risk of hyperhomocysteinemia. |
| format | Article |
| id | doaj-art-445e407ee7ae4c62a03f8f4f5b3c3266 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | BMJ Publishing Group |
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| spelling | doaj-art-445e407ee7ae4c62a03f8f4f5b3c32662024-12-10T03:35:11ZengBMJ Publishing GroupBMJ Open2044-60552021-12-01111210.1136/bmjopen-2020-048575Prevalence and risk factors for hyperhomocysteinemia: a population-based cross-sectional study from Hunan, ChinaYanhui Dong0Yide Yang1Jian Li2Yuan Lv3Yuan Zeng4Shuqian Yuan5Ming Xie6Quanyuan He7Xiangli Ye8Carl-Friedrich Hocher9Bernhard K Kraemer10Xiuqin Hong11Berthold Hocher125 Institute of Child and Adolescent Health & School of Public Health, Peking University, Beijing, ChinaKey Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, Changsha, Hunan, ChinaSports Medicine Center, Sichuan University West China Hospital, Chengdu, Sichuan, ChinaKey Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, Changsha, Hunan, ChinaKey Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, Changsha, Hunan, ChinaKey Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, Changsha, Hunan, ChinaKey Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, Changsha, Hunan, ChinaKey Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, Changsha, Hunan, ChinaKey Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, Changsha, Hunan, ChinaFifth Department of Medicine (Nephrology/Endocrinology/Rheumatology), University Medical Centre Mannheim, University of Heidelberg, Mannheim, GermanyFifth Department of Medicine (Nephrology/Endocrinology/Rheumatology), University Medical Centre Mannheim, University of Heidelberg, Mannheim, GermanyKey Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, Changsha, Hunan, ChinaKey Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Medicine, Hunan Normal University, Changsha, Hunan, ChinaObjectives Hyperhomocysteinemia is an independent risk factor for cardiovascular diseases. We aimed to investigate the prevalence and risk factors for hyperhomocysteinemia, especially modifiable lifestyle factors, such as smoking behaviour and dietary factors.Design Population-based cross-sectional study.Setting Hunan Province, ChinaParticipants A total of 4012 participants completed the study, between July 2013 and March 2014. The median age is 55 (interquartile range: 45–63) years, with 1644 males (41%) and 2368 females (59%).Main outcome measures Homocysteine level were measured by the microplate enzyme immunoassay method. Hyperthomocysteinemia was defined as ≥15 µmol/L. Questionnaire was used to investigate potential risk factors of hyperhomocysteinemia. Crude odd ratio (OR) or adjusted OR with 95% CI were determined by using univariable or multivariable logistic regression models.Results The prevalence of hyperhomocysteinemia is 35.4% (45.4% vs 28.5% for men, women, respectively). One-year increase in age is significantly associated with 2% higher risk of hyperhomocysteinemia (OR=1.02, 95% CI: 1.01 to 1.03). One unit increase of BMI is associated with 5% higher risk of hyperhomocysteinemia (OR=1.05, 95% CI: 1.03 to 1.07). Compared with the non-smoker, smoking participants have a 24% higher risk of hyperhomocysteinemia (OR=1.24, 95% CI: 1.006 to 1.53), while the risk for those quitting smoking are not significantly different (OR=1.14, 95% CI: 0.85 to 1.54). compared with those consuming fruit and vegetable at least once every day, those consuming less than once every day had a significantly higher risk of hyperhomocysteinemia (OR=1.29, 95% CI:1.11 to 1.50). In addition, we found there were significant sex interaction with education level or alcohol drinking on the risk of hyperhomocysteinemia (pinteraction <0.05).Conclusions Higher BMI and older age are potential risk factors for hyperhomocysteinemia. Current smoking but not quitting smoking is associated with higher risk of hyperhomocysteinemia. Fruit and vegetable consumption may have protective effect against hyperhomocysteinemia. Alcohol consumption or education level might interact to influence the risk of hyperhomocysteinemia.https://bmjopen.bmj.com/content/11/12/e048575.full |
| spellingShingle | Yanhui Dong Yide Yang Jian Li Yuan Lv Yuan Zeng Shuqian Yuan Ming Xie Quanyuan He Xiangli Ye Carl-Friedrich Hocher Bernhard K Kraemer Xiuqin Hong Berthold Hocher Prevalence and risk factors for hyperhomocysteinemia: a population-based cross-sectional study from Hunan, China BMJ Open |
| title | Prevalence and risk factors for hyperhomocysteinemia: a population-based cross-sectional study from Hunan, China |
| title_full | Prevalence and risk factors for hyperhomocysteinemia: a population-based cross-sectional study from Hunan, China |
| title_fullStr | Prevalence and risk factors for hyperhomocysteinemia: a population-based cross-sectional study from Hunan, China |
| title_full_unstemmed | Prevalence and risk factors for hyperhomocysteinemia: a population-based cross-sectional study from Hunan, China |
| title_short | Prevalence and risk factors for hyperhomocysteinemia: a population-based cross-sectional study from Hunan, China |
| title_sort | prevalence and risk factors for hyperhomocysteinemia a population based cross sectional study from hunan china |
| url | https://bmjopen.bmj.com/content/11/12/e048575.full |
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