MANF inhibits NLRP3 inflammasome activation by competitively binding to DDX3X in paraquat-stimulated alveolar macrophages

MANF inhibits NLRP3 inflammasome activation by competitively binding to DDX3X in paraquat-stimulated alveolar macrophages

NLRP3 inflammasome activation in macrophages is involved in paraquat-induced acute lung injury (ALI). MANF exerts an inhibitory effect against inflammation and cell death. The aim of this study was to investigate the role of MANF in paraquat-stimulated alveolar macrophages and the potential mechanis...

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Bibliographic Details
Main Authors: Yi Pu, Siying Han, Jie Chen, Zhenning Liu
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Paraquat
Acute lung injury
MANF
DDX3X
NLRP3 inflammasome
Macrophage
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651324014076
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