Uncovering therapeutic targets for Pre-eclampsia and pregnancy hypertension via multi-tissue data integration
Abstract Background Pre-eclampsia (PE) and pregnancy hypertension (PH) are common and serious complications during pregnancy, which can lead to maternal and fetal death in severe cases. Therefore, further research on the potential therapeutic targets of PE and PH is of great significance for develop...
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BMC
2025-04-01
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| Series: | BMC Pregnancy and Childbirth |
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| Online Access: | https://doi.org/10.1186/s12884-025-07608-x |
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| author | Hang Yao Jiahao Chen Yu Wang Yuxin Li Peiyu Tang Mingpeng Liang Qingling Jiang |
| author_facet | Hang Yao Jiahao Chen Yu Wang Yuxin Li Peiyu Tang Mingpeng Liang Qingling Jiang |
| author_sort | Hang Yao |
| collection | DOAJ |
| description | Abstract Background Pre-eclampsia (PE) and pregnancy hypertension (PH) are common and serious complications during pregnancy, which can lead to maternal and fetal death in severe cases. Therefore, further research on the potential therapeutic targets of PE and PH is of great significance for developing new treatment strategies. Methods This study used the summary data-based Mendelian randomization (SMR) method to analyze expression quantitative trait loci (eQTL) data from blood, aorta, and uterus with Genome-wide association studies (GWAS) data on PE and PH, exploring potential genetic loci involved in PE and PH. Since proteinuria is a clinical manifestation of PE, we also analyzed genes related to the kidney and PE. The HEIDI test was used for heterogeneity testing, and results were adjusted using FDR. The cis-eQTL data were obtained from the blood summary-level data of the eQTLGen Consortium and the aorta and uterus data from the V8 release of the GTEx eQTL summary data. The GWAS data for PE and PH were obtained from the FinnGen Documentation of R10 release. This study utilized the STROBE-MR checklist for reporting Mendelian Randomization (MR) studies. Results This study identified several potential therapeutic targets by integrating eQTL data from blood, uterus, and aorta with GWAS data for PE and PH, as well as kidney eQTL data with GWAS data for PE. Additionally, the study discovered some genes with common roles in PE and PH, offering new insights into the shared pathological mechanisms of these two conditions. These findings not only provide new clues to the pathogenesis of PE and PH but also offer crucial foundational data for the development of future therapeutic strategies. Conclusion This study revealed multiple potential therapeutic targets for PE and PH, providing new insights for basic experimental research and clinical treatment to mitigate the severe consequences of PE and PH. Clinical trial number Not applicable. |
| format | Article |
| id | doaj-art-443a3ff37b7d47e4b0f2b22bb24a1e21 |
| institution | Kabale University |
| issn | 1471-2393 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj-art-443a3ff37b7d47e4b0f2b22bb24a1e212025-08-20T03:53:32ZengBMCBMC Pregnancy and Childbirth1471-23932025-04-0125111110.1186/s12884-025-07608-xUncovering therapeutic targets for Pre-eclampsia and pregnancy hypertension via multi-tissue data integrationHang Yao0Jiahao Chen1Yu Wang2Yuxin Li3Peiyu Tang4Mingpeng Liang5Qingling Jiang6School of Traditional Chinese Medicine, Binzhou Medical UniversitySchool of Basic Medical Sciences, Zhejiang Chinese Medical UniversityGraduate School of Jiangxi University of Traditional Chinese MedicineGraduate School of Jiangxi University of Traditional Chinese MedicineSchool of Traditional Chinese Medicine, Binzhou Medical UniversitySchool of Traditional Chinese Medicine, Binzhou Medical UniversitySchool of Traditional Chinese Medicine, Binzhou Medical UniversityAbstract Background Pre-eclampsia (PE) and pregnancy hypertension (PH) are common and serious complications during pregnancy, which can lead to maternal and fetal death in severe cases. Therefore, further research on the potential therapeutic targets of PE and PH is of great significance for developing new treatment strategies. Methods This study used the summary data-based Mendelian randomization (SMR) method to analyze expression quantitative trait loci (eQTL) data from blood, aorta, and uterus with Genome-wide association studies (GWAS) data on PE and PH, exploring potential genetic loci involved in PE and PH. Since proteinuria is a clinical manifestation of PE, we also analyzed genes related to the kidney and PE. The HEIDI test was used for heterogeneity testing, and results were adjusted using FDR. The cis-eQTL data were obtained from the blood summary-level data of the eQTLGen Consortium and the aorta and uterus data from the V8 release of the GTEx eQTL summary data. The GWAS data for PE and PH were obtained from the FinnGen Documentation of R10 release. This study utilized the STROBE-MR checklist for reporting Mendelian Randomization (MR) studies. Results This study identified several potential therapeutic targets by integrating eQTL data from blood, uterus, and aorta with GWAS data for PE and PH, as well as kidney eQTL data with GWAS data for PE. Additionally, the study discovered some genes with common roles in PE and PH, offering new insights into the shared pathological mechanisms of these two conditions. These findings not only provide new clues to the pathogenesis of PE and PH but also offer crucial foundational data for the development of future therapeutic strategies. Conclusion This study revealed multiple potential therapeutic targets for PE and PH, providing new insights for basic experimental research and clinical treatment to mitigate the severe consequences of PE and PH. Clinical trial number Not applicable.https://doi.org/10.1186/s12884-025-07608-xPre-eclampsiaPregnancy hypertensionTherapeutic targetsSummary data-based Mendelian randomizationGenome-wide association studiesExpression quantitative trait loci |
| spellingShingle | Hang Yao Jiahao Chen Yu Wang Yuxin Li Peiyu Tang Mingpeng Liang Qingling Jiang Uncovering therapeutic targets for Pre-eclampsia and pregnancy hypertension via multi-tissue data integration BMC Pregnancy and Childbirth Pre-eclampsia Pregnancy hypertension Therapeutic targets Summary data-based Mendelian randomization Genome-wide association studies Expression quantitative trait loci |
| title | Uncovering therapeutic targets for Pre-eclampsia and pregnancy hypertension via multi-tissue data integration |
| title_full | Uncovering therapeutic targets for Pre-eclampsia and pregnancy hypertension via multi-tissue data integration |
| title_fullStr | Uncovering therapeutic targets for Pre-eclampsia and pregnancy hypertension via multi-tissue data integration |
| title_full_unstemmed | Uncovering therapeutic targets for Pre-eclampsia and pregnancy hypertension via multi-tissue data integration |
| title_short | Uncovering therapeutic targets for Pre-eclampsia and pregnancy hypertension via multi-tissue data integration |
| title_sort | uncovering therapeutic targets for pre eclampsia and pregnancy hypertension via multi tissue data integration |
| topic | Pre-eclampsia Pregnancy hypertension Therapeutic targets Summary data-based Mendelian randomization Genome-wide association studies Expression quantitative trait loci |
| url | https://doi.org/10.1186/s12884-025-07608-x |
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