The expression and clinical significance of PTK7 in oral squamous cell carcinoma
[Objective] To evaluate the expression of protein tyrosine kinase 7 (PTK7) in oral squamous cell carcinoma (OSCC), and to analyze the role of PTK7 protein expression in OSCC and its impact on the prognosis of patients. [Methods] We collected 113 specimens of OSCC, and the PTK7 protein expression was...
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Editorial Office of Journal of Oral and Maxillofacial Surgery
2023-04-01
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| Series: | Kouqiang hemian waike zazhi |
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| Online Access: | https://journal06.magtech.org.cn/Jweb_joms/EN/10.3969/j.issn.1005-4979.2023.02.007 |
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| _version_ | 1849225093247401984 |
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| author | JIA Guodong WANG Yi XU Zhen |
| author_facet | JIA Guodong WANG Yi XU Zhen |
| author_sort | JIA Guodong |
| collection | DOAJ |
| description | [Objective] To evaluate the expression of protein tyrosine kinase 7 (PTK7) in oral squamous cell carcinoma (OSCC), and to analyze the role of PTK7 protein expression in OSCC and its impact on the prognosis of patients. [Methods] We collected 113 specimens of OSCC, and the PTK7 protein expression was determined by streptavidin perosidase (SP) method. The chi‐square test and Kaplan‐Meier analysis were used for the analysis of the expression of PTK7 protein and the OSCC clinical related factors. [Results] In the 113 OSCC specimens, PTK7 protein expressed positive was found in 70 cases, PTK7 protein expressed negative was found in the para‐cancer area. The PTK7 expression intensity was not significantly associated with the patients' age, gender,differentiation degree, clinical stage, tumor size, local infiltration extent and lymph node metastasis (P≥0.05). Kaplan‐Meier survival analysis showed that the survival rate of PTK7 negative patients was significantly higher than that of positive patients (P<0.05). [Conclusion] These findings suggested that the detection of PTK7 protein may aid in the comprehensive assessment of OSCC outcome.Further research for direct measurement are needed. |
| format | Article |
| id | doaj-art-443505a9589b4544b965d429b50eae85 |
| institution | Kabale University |
| issn | 1005-4979 |
| language | zho |
| publishDate | 2023-04-01 |
| publisher | Editorial Office of Journal of Oral and Maxillofacial Surgery |
| record_format | Article |
| series | Kouqiang hemian waike zazhi |
| spelling | doaj-art-443505a9589b4544b965d429b50eae852025-08-25T06:09:58ZzhoEditorial Office of Journal of Oral and Maxillofacial SurgeryKouqiang hemian waike zazhi1005-49792023-04-013329910310.3969/j.issn.1005-4979.2023.02.007The expression and clinical significance of PTK7 in oral squamous cell carcinomaJIA Guodong0WANG Yi1XU Zhen2Department of General Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai 200011, ChinaDepartment of General Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai 200011, ChinaDepartment of General Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai 200011, China[Objective] To evaluate the expression of protein tyrosine kinase 7 (PTK7) in oral squamous cell carcinoma (OSCC), and to analyze the role of PTK7 protein expression in OSCC and its impact on the prognosis of patients. [Methods] We collected 113 specimens of OSCC, and the PTK7 protein expression was determined by streptavidin perosidase (SP) method. The chi‐square test and Kaplan‐Meier analysis were used for the analysis of the expression of PTK7 protein and the OSCC clinical related factors. [Results] In the 113 OSCC specimens, PTK7 protein expressed positive was found in 70 cases, PTK7 protein expressed negative was found in the para‐cancer area. The PTK7 expression intensity was not significantly associated with the patients' age, gender,differentiation degree, clinical stage, tumor size, local infiltration extent and lymph node metastasis (P≥0.05). Kaplan‐Meier survival analysis showed that the survival rate of PTK7 negative patients was significantly higher than that of positive patients (P<0.05). [Conclusion] These findings suggested that the detection of PTK7 protein may aid in the comprehensive assessment of OSCC outcome.Further research for direct measurement are needed.https://journal06.magtech.org.cn/Jweb_joms/EN/10.3969/j.issn.1005-4979.2023.02.007oral squamous cell carcinomaprotein tyrosine kinase 7immunohistochemistry |
| spellingShingle | JIA Guodong WANG Yi XU Zhen The expression and clinical significance of PTK7 in oral squamous cell carcinoma Kouqiang hemian waike zazhi oral squamous cell carcinoma protein tyrosine kinase 7 immunohistochemistry |
| title | The expression and clinical significance of PTK7 in oral squamous cell carcinoma |
| title_full | The expression and clinical significance of PTK7 in oral squamous cell carcinoma |
| title_fullStr | The expression and clinical significance of PTK7 in oral squamous cell carcinoma |
| title_full_unstemmed | The expression and clinical significance of PTK7 in oral squamous cell carcinoma |
| title_short | The expression and clinical significance of PTK7 in oral squamous cell carcinoma |
| title_sort | expression and clinical significance of ptk7 in oral squamous cell carcinoma |
| topic | oral squamous cell carcinoma protein tyrosine kinase 7 immunohistochemistry |
| url | https://journal06.magtech.org.cn/Jweb_joms/EN/10.3969/j.issn.1005-4979.2023.02.007 |
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