DNA-Based Technology for Herpesvirus Detection
The detection of viral DNA is considered crucial in both diagnosis and prognosis. Nowadays, molecular diagnostic approaches represent the most promising tools for the clinical detection of viral infections. This review aims to investigate the most used and promising DNA-based technologies for viral...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-12-01
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| Series: | DNA |
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| Online Access: | https://www.mdpi.com/2673-8856/4/4/37 |
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| _version_ | 1846104984684331008 |
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| author | Gloria Maini Giorgia Cianci Matteo Ferraresi Valentina Gentili Daria Bortolotti |
| author_facet | Gloria Maini Giorgia Cianci Matteo Ferraresi Valentina Gentili Daria Bortolotti |
| author_sort | Gloria Maini |
| collection | DOAJ |
| description | The detection of viral DNA is considered crucial in both diagnosis and prognosis. Nowadays, molecular diagnostic approaches represent the most promising tools for the clinical detection of viral infections. This review aims to investigate the most used and promising DNA-based technologies for viral detection, focusing on herpesviruses because of their ability to undergo latent and reactivation cycles, persisting lifelong in the host in association with several diseases. Molecular technologies, such as PCR-based assays, enhance sensitivity and specificity in identifying viral DNA from clinical samples such as blood, cerebrospinal fluid and saliva, indicating PCR and its derivatives as the gold standard methods for herpesvirus detection. In conclusion, this review underscores the need for continuous innovation in diagnostic methodologies to address the complexities of herpesvirus identification in different clinical samples. |
| format | Article |
| id | doaj-art-4431b6a39d6a456a8ecb4ea3d9795fa3 |
| institution | Kabale University |
| issn | 2673-8856 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | DNA |
| spelling | doaj-art-4431b6a39d6a456a8ecb4ea3d9795fa32024-12-27T14:21:41ZengMDPI AGDNA2673-88562024-12-014455358110.3390/dna4040037DNA-Based Technology for Herpesvirus DetectionGloria Maini0Giorgia Cianci1Matteo Ferraresi2Valentina Gentili3Daria Bortolotti4Department of Environmental and Prevention Sciences, University of Ferrara, 44121 Ferrara, ItalyDepartment of Environmental and Prevention Sciences, University of Ferrara, 44121 Ferrara, ItalyDepartment of Environmental and Prevention Sciences, University of Ferrara, 44121 Ferrara, ItalyDepartment of Environmental and Prevention Sciences, University of Ferrara, 44121 Ferrara, ItalyDepartment of Environmental and Prevention Sciences, University of Ferrara, 44121 Ferrara, ItalyThe detection of viral DNA is considered crucial in both diagnosis and prognosis. Nowadays, molecular diagnostic approaches represent the most promising tools for the clinical detection of viral infections. This review aims to investigate the most used and promising DNA-based technologies for viral detection, focusing on herpesviruses because of their ability to undergo latent and reactivation cycles, persisting lifelong in the host in association with several diseases. Molecular technologies, such as PCR-based assays, enhance sensitivity and specificity in identifying viral DNA from clinical samples such as blood, cerebrospinal fluid and saliva, indicating PCR and its derivatives as the gold standard methods for herpesvirus detection. In conclusion, this review underscores the need for continuous innovation in diagnostic methodologies to address the complexities of herpesvirus identification in different clinical samples.https://www.mdpi.com/2673-8856/4/4/37viral DNA detectionherpesvirusclinical samples |
| spellingShingle | Gloria Maini Giorgia Cianci Matteo Ferraresi Valentina Gentili Daria Bortolotti DNA-Based Technology for Herpesvirus Detection DNA viral DNA detection herpesvirus clinical samples |
| title | DNA-Based Technology for Herpesvirus Detection |
| title_full | DNA-Based Technology for Herpesvirus Detection |
| title_fullStr | DNA-Based Technology for Herpesvirus Detection |
| title_full_unstemmed | DNA-Based Technology for Herpesvirus Detection |
| title_short | DNA-Based Technology for Herpesvirus Detection |
| title_sort | dna based technology for herpesvirus detection |
| topic | viral DNA detection herpesvirus clinical samples |
| url | https://www.mdpi.com/2673-8856/4/4/37 |
| work_keys_str_mv | AT gloriamaini dnabasedtechnologyforherpesvirusdetection AT giorgiacianci dnabasedtechnologyforherpesvirusdetection AT matteoferraresi dnabasedtechnologyforherpesvirusdetection AT valentinagentili dnabasedtechnologyforherpesvirusdetection AT dariabortolotti dnabasedtechnologyforherpesvirusdetection |