Introducing an index on prediction of post-revascularization cerebral infarction using preoperative CT perfusion parameters in moyamoya disease
Abstract Objective To determine the value of preoperative CT perfusion (CTP) parameters for prediction of post-revascularization cerebral infarction (post-CI) in adults with moyamoya disease (MMD). Methods This retrospective study included 92 adults with MMD who underwent surgical revascularization....
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SpringerOpen
2025-01-01
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| Series: | Insights into Imaging |
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| Online Access: | https://doi.org/10.1186/s13244-024-01882-7 |
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| author | Xiaojun Hao Chao Zhang Chen Yang Xintong Zhao Yunfeng Zhou Juan Wang |
| author_facet | Xiaojun Hao Chao Zhang Chen Yang Xintong Zhao Yunfeng Zhou Juan Wang |
| author_sort | Xiaojun Hao |
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| description | Abstract Objective To determine the value of preoperative CT perfusion (CTP) parameters for prediction of post-revascularization cerebral infarction (post-CI) in adults with moyamoya disease (MMD). Methods This retrospective study included 92 adults with MMD who underwent surgical revascularization. Preoperative quantitative CTP parameters, including cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), time to drain (TTD), and transit time to maximum of the residue function (Tmax), along with clinical data, were compared between the groups with and without post-CI. Predictors of post-CI were identified and assessed using multivariable logistic regression and receiver-operating characteristic curve analyses. Results Post-CI occurred in 11 patients (12.0%). In univariate analysis, preoperative mean values for CBF, MTT, TTD, Tmax, initial presentation, infarction within the 2 months before surgery, surgical side, and modified Rankin Scale score on admission were associated with post-CI (all p < 0.05). Multivariable logistic regression revealed that the preoperative mean Tmax (OR 2.342, 95% CI: 1.267–4.330, p = 0.007) and infarction within the 2 months before surgery (OR 14.345, 95% CI: 2.108–97.638, p = 0.006) were independent predictors of post-CI. The preoperative mean Tmax produced the largest area under the curve (0.955, 95% CI: 0.914–0.997) with a cutoff of 3.590 s (sensitivity, 100%; specificity, 87.7%). Conclusions Adults with MMD are at risk of post-CI when the preoperative mean Tmax is > 3.590 s. Cerebral infarction during the 2 months before revascularization is also a risk factor for post-CI. Critical relevance statement Post-CI is a serious complication for adults with MMD following surgical revascularization. The risk of post-CI can be predicted using preoperative CTP parameters, which will assist neurosurgeons with surgical decisions and implementing individualized prophylactic strategies. Key Points Predicting the risk of post-CI in MMD patients is beneficial to their prognosis. The preoperative mean Tmax was an excellent perfusion parameter for predicting post-CI. Preoperative CTP evaluation can help clinicians make cautious surgical decisions. Graphical Abstract |
| format | Article |
| id | doaj-art-441bb0d27c7448f287a2095bed9975ef |
| institution | Kabale University |
| issn | 1869-4101 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SpringerOpen |
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| series | Insights into Imaging |
| spelling | doaj-art-441bb0d27c7448f287a2095bed9975ef2025-01-05T12:32:38ZengSpringerOpenInsights into Imaging1869-41012025-01-011611910.1186/s13244-024-01882-7Introducing an index on prediction of post-revascularization cerebral infarction using preoperative CT perfusion parameters in moyamoya diseaseXiaojun Hao0Chao Zhang1Chen Yang2Xintong Zhao3Yunfeng Zhou4Juan Wang5Department of Radiology, The First Affiliated Hospital of Wannan Medical CollegeDepartment of Radiology, The First Affiliated Hospital of Wannan Medical CollegeDepartment of Radiology, The First Affiliated Hospital of Wannan Medical CollegeDepartment of Neurosurgery, The First Affiliated Hospital of Wannan Medical CollegeDepartment of Radiology, The First Affiliated Hospital of Wannan Medical CollegeDepartment of Radiology, The First Affiliated Hospital of Wannan Medical CollegeAbstract Objective To determine the value of preoperative CT perfusion (CTP) parameters for prediction of post-revascularization cerebral infarction (post-CI) in adults with moyamoya disease (MMD). Methods This retrospective study included 92 adults with MMD who underwent surgical revascularization. Preoperative quantitative CTP parameters, including cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), time to drain (TTD), and transit time to maximum of the residue function (Tmax), along with clinical data, were compared between the groups with and without post-CI. Predictors of post-CI were identified and assessed using multivariable logistic regression and receiver-operating characteristic curve analyses. Results Post-CI occurred in 11 patients (12.0%). In univariate analysis, preoperative mean values for CBF, MTT, TTD, Tmax, initial presentation, infarction within the 2 months before surgery, surgical side, and modified Rankin Scale score on admission were associated with post-CI (all p < 0.05). Multivariable logistic regression revealed that the preoperative mean Tmax (OR 2.342, 95% CI: 1.267–4.330, p = 0.007) and infarction within the 2 months before surgery (OR 14.345, 95% CI: 2.108–97.638, p = 0.006) were independent predictors of post-CI. The preoperative mean Tmax produced the largest area under the curve (0.955, 95% CI: 0.914–0.997) with a cutoff of 3.590 s (sensitivity, 100%; specificity, 87.7%). Conclusions Adults with MMD are at risk of post-CI when the preoperative mean Tmax is > 3.590 s. Cerebral infarction during the 2 months before revascularization is also a risk factor for post-CI. Critical relevance statement Post-CI is a serious complication for adults with MMD following surgical revascularization. The risk of post-CI can be predicted using preoperative CTP parameters, which will assist neurosurgeons with surgical decisions and implementing individualized prophylactic strategies. Key Points Predicting the risk of post-CI in MMD patients is beneficial to their prognosis. The preoperative mean Tmax was an excellent perfusion parameter for predicting post-CI. Preoperative CTP evaluation can help clinicians make cautious surgical decisions. Graphical Abstracthttps://doi.org/10.1186/s13244-024-01882-7Moyamoya diseaseCerebral revascularizationCerebral infarctionPerfusion imagingTomography (X-ray computed) |
| spellingShingle | Xiaojun Hao Chao Zhang Chen Yang Xintong Zhao Yunfeng Zhou Juan Wang Introducing an index on prediction of post-revascularization cerebral infarction using preoperative CT perfusion parameters in moyamoya disease Insights into Imaging Moyamoya disease Cerebral revascularization Cerebral infarction Perfusion imaging Tomography (X-ray computed) |
| title | Introducing an index on prediction of post-revascularization cerebral infarction using preoperative CT perfusion parameters in moyamoya disease |
| title_full | Introducing an index on prediction of post-revascularization cerebral infarction using preoperative CT perfusion parameters in moyamoya disease |
| title_fullStr | Introducing an index on prediction of post-revascularization cerebral infarction using preoperative CT perfusion parameters in moyamoya disease |
| title_full_unstemmed | Introducing an index on prediction of post-revascularization cerebral infarction using preoperative CT perfusion parameters in moyamoya disease |
| title_short | Introducing an index on prediction of post-revascularization cerebral infarction using preoperative CT perfusion parameters in moyamoya disease |
| title_sort | introducing an index on prediction of post revascularization cerebral infarction using preoperative ct perfusion parameters in moyamoya disease |
| topic | Moyamoya disease Cerebral revascularization Cerebral infarction Perfusion imaging Tomography (X-ray computed) |
| url | https://doi.org/10.1186/s13244-024-01882-7 |
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