Complete Resolution of Hemodialysis-induced Pseudoporphyria after Renal Transplantation
Bullous dermatoses in end-stage renal disease are not an uncommon entity. A high index of clinical suspicion is essential for the proper diagnosis of rare dermatological diseases in chronic kidney disease patients. Pseudoporphyria (PP) should consider in differential diagnosis of bullous dermatoses...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Indian Journal of Transplantation |
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| Online Access: | https://journals.lww.com/10.4103/ijot.ijot_2_24 |
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| author | Prodip Kumar Doley Oyik Tamut Manjuri Sharma Gayatri Pegu |
| author_facet | Prodip Kumar Doley Oyik Tamut Manjuri Sharma Gayatri Pegu |
| author_sort | Prodip Kumar Doley |
| collection | DOAJ |
| description | Bullous dermatoses in end-stage renal disease are not an uncommon entity. A high index of clinical suspicion is essential for the proper diagnosis of rare dermatological diseases in chronic kidney disease patients. Pseudoporphyria (PP) should consider in differential diagnosis of bullous dermatoses in patients on Maintenance hemodialysis (MHD). PP is a photo-distributed bullous disorder with clinical and histologic features of porphyria cutanea tarda (PCT) but without accompanying biochemical porphyrin abnormalities. PP is a blistering disease with skin fragility and shallow scarring that clinically and histopathologically closely resembles PCT. The two conditions can be distinguished by porphyrin levels that typically are elevated in PCT, but not or only slightly in PP. PP can be induced by various medications (e.g. nonsteroidal anti-inflammatory drugs, antibiotics, diuretics, and retinoids), intense ultraviolet (A) exposure, or hemodialysis. Treatment of hemodialysis-associated PP is not yet standardized. Here, we report a case of pseudoporphyria in a patient on maintenance hemodialysis, refractory to the conventional treatment, and who subsequently underwent successful renal transplantation with full resolution of skin lesions within a month. |
| format | Article |
| id | doaj-art-44132f0b12fe41d8a8dcb8bf7d954e49 |
| institution | Kabale University |
| issn | 2212-0017 2212-0025 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Transplantation |
| spelling | doaj-art-44132f0b12fe41d8a8dcb8bf7d954e492025-01-07T06:12:53ZengWolters Kluwer Medknow PublicationsIndian Journal of Transplantation2212-00172212-00252024-12-0118444544810.4103/ijot.ijot_2_24Complete Resolution of Hemodialysis-induced Pseudoporphyria after Renal TransplantationProdip Kumar DoleyOyik TamutManjuri SharmaGayatri PeguBullous dermatoses in end-stage renal disease are not an uncommon entity. A high index of clinical suspicion is essential for the proper diagnosis of rare dermatological diseases in chronic kidney disease patients. Pseudoporphyria (PP) should consider in differential diagnosis of bullous dermatoses in patients on Maintenance hemodialysis (MHD). PP is a photo-distributed bullous disorder with clinical and histologic features of porphyria cutanea tarda (PCT) but without accompanying biochemical porphyrin abnormalities. PP is a blistering disease with skin fragility and shallow scarring that clinically and histopathologically closely resembles PCT. The two conditions can be distinguished by porphyrin levels that typically are elevated in PCT, but not or only slightly in PP. PP can be induced by various medications (e.g. nonsteroidal anti-inflammatory drugs, antibiotics, diuretics, and retinoids), intense ultraviolet (A) exposure, or hemodialysis. Treatment of hemodialysis-associated PP is not yet standardized. Here, we report a case of pseudoporphyria in a patient on maintenance hemodialysis, refractory to the conventional treatment, and who subsequently underwent successful renal transplantation with full resolution of skin lesions within a month.https://journals.lww.com/10.4103/ijot.ijot_2_24bullous dermatosisend-stage renal diseasepseudoporphyria |
| spellingShingle | Prodip Kumar Doley Oyik Tamut Manjuri Sharma Gayatri Pegu Complete Resolution of Hemodialysis-induced Pseudoporphyria after Renal Transplantation Indian Journal of Transplantation bullous dermatosis end-stage renal disease pseudoporphyria |
| title | Complete Resolution of Hemodialysis-induced Pseudoporphyria after Renal Transplantation |
| title_full | Complete Resolution of Hemodialysis-induced Pseudoporphyria after Renal Transplantation |
| title_fullStr | Complete Resolution of Hemodialysis-induced Pseudoporphyria after Renal Transplantation |
| title_full_unstemmed | Complete Resolution of Hemodialysis-induced Pseudoporphyria after Renal Transplantation |
| title_short | Complete Resolution of Hemodialysis-induced Pseudoporphyria after Renal Transplantation |
| title_sort | complete resolution of hemodialysis induced pseudoporphyria after renal transplantation |
| topic | bullous dermatosis end-stage renal disease pseudoporphyria |
| url | https://journals.lww.com/10.4103/ijot.ijot_2_24 |
| work_keys_str_mv | AT prodipkumardoley completeresolutionofhemodialysisinducedpseudoporphyriaafterrenaltransplantation AT oyiktamut completeresolutionofhemodialysisinducedpseudoporphyriaafterrenaltransplantation AT manjurisharma completeresolutionofhemodialysisinducedpseudoporphyriaafterrenaltransplantation AT gayatripegu completeresolutionofhemodialysisinducedpseudoporphyriaafterrenaltransplantation |