Complete Resolution of Hemodialysis-induced Pseudoporphyria after Renal Transplantation

Complete Resolution of Hemodialysis-induced Pseudoporphyria after Renal Transplantation

Bullous dermatoses in end-stage renal disease are not an uncommon entity. A high index of clinical suspicion is essential for the proper diagnosis of rare dermatological diseases in chronic kidney disease patients. Pseudoporphyria (PP) should consider in differential diagnosis of bullous dermatoses...

Full description

Saved in:
Bibliographic Details
Main Authors: Prodip Kumar Doley, Oyik Tamut, Manjuri Sharma, Gayatri Pegu
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2024-12-01
Series:Indian Journal of Transplantation
Subjects:
bullous dermatosis
end-stage renal disease
pseudoporphyria
Online Access:https://journals.lww.com/10.4103/ijot.ijot_2_24
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Bullous dermatoses in end-stage renal disease are not an uncommon entity. A high index of clinical suspicion is essential for the proper diagnosis of rare dermatological diseases in chronic kidney disease patients. Pseudoporphyria (PP) should consider in differential diagnosis of bullous dermatoses in patients on Maintenance hemodialysis (MHD). PP is a photo-distributed bullous disorder with clinical and histologic features of porphyria cutanea tarda (PCT) but without accompanying biochemical porphyrin abnormalities. PP is a blistering disease with skin fragility and shallow scarring that clinically and histopathologically closely resembles PCT. The two conditions can be distinguished by porphyrin levels that typically are elevated in PCT, but not or only slightly in PP. PP can be induced by various medications (e.g. nonsteroidal anti-inflammatory drugs, antibiotics, diuretics, and retinoids), intense ultraviolet (A) exposure, or hemodialysis. Treatment of hemodialysis-associated PP is not yet standardized. Here, we report a case of pseudoporphyria in a patient on maintenance hemodialysis, refractory to the conventional treatment, and who subsequently underwent successful renal transplantation with full resolution of skin lesions within a month.
ISSN:2212-0017
2212-0025

Similar Items