Gene expression and molecular pathway analyses differentiate immunotherapy-induced myositis from spontaneous dermatomyositis

Gene expression and molecular pathway analyses differentiate immunotherapy-induced myositis from spontaneous dermatomyositis

Abstract Immune checkpoint inhibitor therapy (ICI)-induced myositis (irMyositis) occurs in about 1% of patients treated with anti-PD1 or anti-CTLA-4 antibodies and can be debilitating or even fatal. We compared gene expression profiles from skeletal muscle biopsies between irMyositis patients, patie...

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Bibliographic Details
Main Authors: Magdalena Röckel, Luca Musella, Corinna Preusse, Josefine Radke, Lisa Zimmer, Kai-Martin Thoms, Florentia Dimitriou, Matthias Endres, Wolfgang Böhmerle, Waltraud Fröhlich, Sami Tayb-Boulahfa, Sarah Leonard-Louis, Yves Allenbach, Carola Berking, Werner Stenzel, Samuel Knauss, Julio Vera, Lucie Heinzerling
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Gene expression profiles
Immune Related adverse events
Immune checkpoint inhibitor therapy
Myositis
Anti-PD1/PD L1
Anti-CTLA-4
Online Access:https://doi.org/10.1038/s41598-025-11944-5
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