Microfluidic organ-on-chip systems for periodontal research: advances and future directions
Advances in tissue engineering and microfluidic technologies have enabled the development of sophisticated in vitro models known as organ-on-a-chip (OoC) or microphysiological systems. These systems enable to potential to simulate the dynamic interactions between host tissues and their microenvironm...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1490453/full |
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| author | Gopu Sriram Gopu Sriram Hardik Makkar Hardik Makkar |
| author_facet | Gopu Sriram Gopu Sriram Hardik Makkar Hardik Makkar |
| author_sort | Gopu Sriram |
| collection | DOAJ |
| description | Advances in tissue engineering and microfluidic technologies have enabled the development of sophisticated in vitro models known as organ-on-a-chip (OoC) or microphysiological systems. These systems enable to potential to simulate the dynamic interactions between host tissues and their microenvironment including microbes, biomaterials, mechanical forces, pharmaceutical, and consumer-care products. These fluidic technologies are increasingly being utilized to investigate host-microbe and host-material interactions in oral health and disease. Of interest is their application in understanding periodontal disease, a chronic inflammatory condition marked by the progressive destruction of periodontal tissues, including gingiva, periodontal ligament, and alveolar bone. The pathogenesis of periodontal disease involves a complex interplay between microbial dysbiosis and host immune responses, which can lead to a loss of dental support structures and contribute to systemic conditions such as cardiovascular disease, diabetes, and inflammatory bowel disease. This provides a comprehensive overview of the latest developments in millifluidic and microfluidic systems designed to emulate periodontal host-microbe and host-material interactions. We discuss the critical engineering and biological considerations in designing these platforms, their applications in studying oral biofilms, periodontal tissue responses, and their potential to unravel disease mechanisms and therapeutic targets in periodontal disease. |
| format | Article |
| id | doaj-art-43f1e4df1f824e1a9b98949f0e740e7f |
| institution | Kabale University |
| issn | 2296-4185 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-43f1e4df1f824e1a9b98949f0e740e7f2025-01-07T06:45:04ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-01-011210.3389/fbioe.2024.14904531490453Microfluidic organ-on-chip systems for periodontal research: advances and future directionsGopu Sriram0Gopu Sriram1Hardik Makkar2Hardik Makkar3Faculty of Dentistry, National University of Singapore, Singapore, SingaporeDepartment of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore, SingaporeFaculty of Dentistry, National University of Singapore, Singapore, SingaporeCenter for Innovation & Precision Dentistry, School of Dental Medicine and School of Engineering & Applied Sciences, University of Pennsylvania, Philadelphia, PA, United StatesAdvances in tissue engineering and microfluidic technologies have enabled the development of sophisticated in vitro models known as organ-on-a-chip (OoC) or microphysiological systems. These systems enable to potential to simulate the dynamic interactions between host tissues and their microenvironment including microbes, biomaterials, mechanical forces, pharmaceutical, and consumer-care products. These fluidic technologies are increasingly being utilized to investigate host-microbe and host-material interactions in oral health and disease. Of interest is their application in understanding periodontal disease, a chronic inflammatory condition marked by the progressive destruction of periodontal tissues, including gingiva, periodontal ligament, and alveolar bone. The pathogenesis of periodontal disease involves a complex interplay between microbial dysbiosis and host immune responses, which can lead to a loss of dental support structures and contribute to systemic conditions such as cardiovascular disease, diabetes, and inflammatory bowel disease. This provides a comprehensive overview of the latest developments in millifluidic and microfluidic systems designed to emulate periodontal host-microbe and host-material interactions. We discuss the critical engineering and biological considerations in designing these platforms, their applications in studying oral biofilms, periodontal tissue responses, and their potential to unravel disease mechanisms and therapeutic targets in periodontal disease.https://www.frontiersin.org/articles/10.3389/fbioe.2024.1490453/fullperiodontal diseaseorgan-on-a-chipmicrophysiological systemshost-microbe interactionsbiofilmsmicrofluidic systems |
| spellingShingle | Gopu Sriram Gopu Sriram Hardik Makkar Hardik Makkar Microfluidic organ-on-chip systems for periodontal research: advances and future directions Frontiers in Bioengineering and Biotechnology periodontal disease organ-on-a-chip microphysiological systems host-microbe interactions biofilms microfluidic systems |
| title | Microfluidic organ-on-chip systems for periodontal research: advances and future directions |
| title_full | Microfluidic organ-on-chip systems for periodontal research: advances and future directions |
| title_fullStr | Microfluidic organ-on-chip systems for periodontal research: advances and future directions |
| title_full_unstemmed | Microfluidic organ-on-chip systems for periodontal research: advances and future directions |
| title_short | Microfluidic organ-on-chip systems for periodontal research: advances and future directions |
| title_sort | microfluidic organ on chip systems for periodontal research advances and future directions |
| topic | periodontal disease organ-on-a-chip microphysiological systems host-microbe interactions biofilms microfluidic systems |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1490453/full |
| work_keys_str_mv | AT gopusriram microfluidicorganonchipsystemsforperiodontalresearchadvancesandfuturedirections AT gopusriram microfluidicorganonchipsystemsforperiodontalresearchadvancesandfuturedirections AT hardikmakkar microfluidicorganonchipsystemsforperiodontalresearchadvancesandfuturedirections AT hardikmakkar microfluidicorganonchipsystemsforperiodontalresearchadvancesandfuturedirections |