Activated DRP1 promotes mitochondrial fission and induces glycolysis in ATII cells under hyperoxia

Activated DRP1 promotes mitochondrial fission and induces glycolysis in ATII cells under hyperoxia

Abstract Backgroud Recent studies have reported mitochondrial damage and metabolic dysregulation in BPD, but the changes in mitochondrial dynamics and glucose metabolic reprogramming in ATII cells and their regulatory relationship have not been reported. Methods Neonatal rats in this study were divi...

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Bibliographic Details
Main Authors: Tong Sun, Haiyang Yu, Dingning Zhang, Danni Li, Jianhua Fu
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Respiratory Research
Subjects:
Mitochondrial fission
Metabolic reprogramming
Bronchopulmonary dysplasia
ATII cells
DRP1 signaling pathway
Online Access:https://doi.org/10.1186/s12931-024-03083-8
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