Clinical characteristics and treatment strategies for A20 haploinsufficiency in Japan: a national epidemiological survey

Clinical characteristics and treatment strategies for A20 haploinsufficiency in Japan: a national epidemiological survey

BackgroundThe severity of A20 haploinsufficiency (HA20) varies, with no established clinical guidelines for treatment. This study aimed to elucidate the clinical characteristics of, and the efficacy of treatments attempted in, patients with HA20 in Japan.MethodsClinical information on HA20 patients...

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Main Authors: Mayuka Shiraki, Saori Kadowaki, Yuki Miwa, Kenichi Nishimura, Yuta Maruyama, Dai Kishida, Kazuo Imagawa, Chie Kobayashi, Hidetoshi Takada, Kanako Mitsunaga, Yuzaburo Inoue, Takasuke Ebato, Takayuki Miyamoto, Eitaro Hiejima, Shuzo Sato, Kiyoshi Migita, Tadashi Matsubayashi, Daisuke Kobayashi, Eriko Hasegawa, Utako Kaneko, Takashi Ishikawa, Masafumi Onodera, Kohei Matsushita, Yuhki Koike, Hiroaki Umebayashi, Fumihiko Kakuta, Daiki Abukawa, Yasutomo Funakoshi, Masataka Ishimura, Yusuke Otani, Takuya Nishizawa, Takashi Ishige, Reiko Hatori, Seiji Tanaka, Shouichirou Kusunoki, Kimitoshi Nakamura, Harumi Shirai, Yoshiho Hatai, Futaba Miyaoka, Shuya Kaneko, Asami Shimbo, Masaki Shimizu, Hirokazu Kanegane, Motomu Hashimoto, Nobuo Negoro, Taro Yoshida, Yasunori Wada, Masaaki Usami, Taizo Wada, Kazushi Izawa, Takahiro Yasumi, Ryuta Nishikomori, Hidenori Ohnishi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
A20 haploinsufficiency
TNFAIP3
autoinflammatory disease
molecular target drugs
secondary failure
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1548042/full
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