NLRP3 deficiency abrogates silica-induced neutrophil infiltration, pulmonary damage and fibrosis

NLRP3 deficiency abrogates silica-induced neutrophil infiltration, pulmonary damage and fibrosis

Abstract Background Silicosis is a progressive and often fatal occupational lung disease. The NLRP3 inflammasome is an innate immune sensor that is activated by silica. Accumulating evidence has implicated a role for NLRP3 in silicosis pathogenesis. In this study, we mechanistically elucidated the c...

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Bibliographic Details
Main Authors: Maggie Lam, Kristian T. Barry, Christopher J. Hodges, Christopher M. Harpur, James D. H. Ong, Sarah Rosli, Alison C. West, Lovisa Dousha, Paul J. Hertzog, Ashley Mansell, Michelle D. Tate
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Respiratory Research
Subjects:
Silicosis
NLRP3 inflammasome
Mouse model
Inflammation
Fibrosis
Online Access:https://doi.org/10.1186/s12931-025-03192-y
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