Application of tight membrane extraction for amines separation
Chiral amines are very valued constituents of many important pharmaceutical compounds and their intermediates. However, the production of a chiral amine encounters some challenges, like the use of harsh conditions and the unfavorable thermodynamic equilibrium. In this research the possibilities of t...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Chemical Engineering |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fceng.2024.1449088/full |
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| author | Sara Salvador Cob Kristien De Sitter Anita Buekenhoudt |
| author_facet | Sara Salvador Cob Kristien De Sitter Anita Buekenhoudt |
| author_sort | Sara Salvador Cob |
| collection | DOAJ |
| description | Chiral amines are very valued constituents of many important pharmaceutical compounds and their intermediates. However, the production of a chiral amine encounters some challenges, like the use of harsh conditions and the unfavorable thermodynamic equilibrium. In this research the possibilities of tight membrane extraction (ME) for amines separation has been investigated to improve the reaction equilibrium. A specific transaminase reaction was selected for the study in which product amine 1-methyl-3-phenylpropylamine (MPPA) or methyl benzylamine (MBA) needs to be separated from the donor amine isopropylamine (IPA). Tight ME is an innovative separation process in which the membrane is not only an interface, but also a way to add extra selectivity to the process. In the present work, we thoroughly discuss the main factors influencing this novel technique by evaluating the extraction efficiency and extraction rates for the different amines. Then we also determine the optimal parameters for the selected reaction. Supported liquid membrane extraction (SLM), as well as pressure driven filtration, more specifically, nanofiltration (NF), were also studied as benchmark technologies, showing that tight ME has a greater advantage over the two in this specific case, due to the extra affinity factor offered by the membrane. The selectivity of MPPA/IPA in tight ME for the optimized parameters was significantly higher than for SLM and NF. |
| format | Article |
| id | doaj-art-43d00b5ebfe14f6bb211b69f86eb70db |
| institution | Kabale University |
| issn | 2673-2718 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemical Engineering |
| spelling | doaj-art-43d00b5ebfe14f6bb211b69f86eb70db2024-11-20T13:13:04ZengFrontiers Media S.A.Frontiers in Chemical Engineering2673-27182024-11-01610.3389/fceng.2024.14490881449088Application of tight membrane extraction for amines separationSara Salvador CobKristien De SitterAnita BuekenhoudtChiral amines are very valued constituents of many important pharmaceutical compounds and their intermediates. However, the production of a chiral amine encounters some challenges, like the use of harsh conditions and the unfavorable thermodynamic equilibrium. In this research the possibilities of tight membrane extraction (ME) for amines separation has been investigated to improve the reaction equilibrium. A specific transaminase reaction was selected for the study in which product amine 1-methyl-3-phenylpropylamine (MPPA) or methyl benzylamine (MBA) needs to be separated from the donor amine isopropylamine (IPA). Tight ME is an innovative separation process in which the membrane is not only an interface, but also a way to add extra selectivity to the process. In the present work, we thoroughly discuss the main factors influencing this novel technique by evaluating the extraction efficiency and extraction rates for the different amines. Then we also determine the optimal parameters for the selected reaction. Supported liquid membrane extraction (SLM), as well as pressure driven filtration, more specifically, nanofiltration (NF), were also studied as benchmark technologies, showing that tight ME has a greater advantage over the two in this specific case, due to the extra affinity factor offered by the membrane. The selectivity of MPPA/IPA in tight ME for the optimized parameters was significantly higher than for SLM and NF.https://www.frontiersin.org/articles/10.3389/fceng.2024.1449088/fulltight membrane extractionchiral aminesaffinity separationprocess optimizationsupported liquid membranes (SLM)nanofiltration (NF) |
| spellingShingle | Sara Salvador Cob Kristien De Sitter Anita Buekenhoudt Application of tight membrane extraction for amines separation Frontiers in Chemical Engineering tight membrane extraction chiral amines affinity separation process optimization supported liquid membranes (SLM) nanofiltration (NF) |
| title | Application of tight membrane extraction for amines separation |
| title_full | Application of tight membrane extraction for amines separation |
| title_fullStr | Application of tight membrane extraction for amines separation |
| title_full_unstemmed | Application of tight membrane extraction for amines separation |
| title_short | Application of tight membrane extraction for amines separation |
| title_sort | application of tight membrane extraction for amines separation |
| topic | tight membrane extraction chiral amines affinity separation process optimization supported liquid membranes (SLM) nanofiltration (NF) |
| url | https://www.frontiersin.org/articles/10.3389/fceng.2024.1449088/full |
| work_keys_str_mv | AT sarasalvadorcob applicationoftightmembraneextractionforaminesseparation AT kristiendesitter applicationoftightmembraneextractionforaminesseparation AT anitabuekenhoudt applicationoftightmembraneextractionforaminesseparation |