Chloramine-T (N-chloro-p-toluenesulfonamide sodium salt), a versatile reagent in organic synthesis and analytical chemistry: An up to date review
Chloramine-T (CAT), the sodium salt of N-chloro-p-toluenesulfonamide, is a low-cost mild oxidizing agent with a wide range of uses. Most importantly, it can be used in acidic, neutral, and basic conditions. As a result, it’s been widely used in chemistry, particularly in organic synthesis and analyt...
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| Format: | Article |
| Language: | English |
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Springer
2022-03-01
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| Series: | Journal of Saudi Chemical Society |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319610321002210 |
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| author | Yogeesha N. Nayak Santosh L. Gaonkar Ebraheem Abdu Musad Saleh Abdullah Mohammed A.L. Dawsari Harshitha Kakul Husain Ismail Hassan |
| author_facet | Yogeesha N. Nayak Santosh L. Gaonkar Ebraheem Abdu Musad Saleh Abdullah Mohammed A.L. Dawsari Harshitha Kakul Husain Ismail Hassan |
| author_sort | Yogeesha N. Nayak |
| collection | DOAJ |
| description | Chloramine-T (CAT), the sodium salt of N-chloro-p-toluenesulfonamide, is a low-cost mild oxidizing agent with a wide range of uses. Most importantly, it can be used in acidic, neutral, and basic conditions. As a result, it’s been widely used in chemistry, particularly in organic synthesis and analytical chemistry. Chloramine-T acts as a source of halonium cation and nitrogen anion and thus acts as base and nucleophile. It reacts with a wide range of functional groups and carries different molecular transformations. This paper thoroughly summarises and highlights the synthetic and analytical effectiveness of CAT. This study focuses on current developments as well as some older techniques in which CAT has been employed as an oxidizing agent. This review article stretches a comprehensive profile of the CAT reagent in organic synthesis and analytical chemistry, which will be very useful for further research exploration in this field. |
| format | Article |
| id | doaj-art-43cacd37d6794e1fb012915f9fe8d10c |
| institution | Kabale University |
| issn | 1319-6103 |
| language | English |
| publishDate | 2022-03-01 |
| publisher | Springer |
| record_format | Article |
| series | Journal of Saudi Chemical Society |
| spelling | doaj-art-43cacd37d6794e1fb012915f9fe8d10c2025-08-20T03:49:08ZengSpringerJournal of Saudi Chemical Society1319-61032022-03-0126210141610.1016/j.jscs.2021.101416Chloramine-T (N-chloro-p-toluenesulfonamide sodium salt), a versatile reagent in organic synthesis and analytical chemistry: An up to date reviewYogeesha N. Nayak0Santosh L. Gaonkar1Ebraheem Abdu Musad Saleh2Abdullah Mohammed A.L. Dawsari3 Harshitha4Kakul Husain5Ismail Hassan6Department of Chemistry, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal 576104, Karnataka, IndiaDepartment of Chemistry, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal 576104, Karnataka, IndiaDepartment of Chemistry, Prince Sattam Bin Abdulaziz University, College of Arts and Science, Wadi Al-Dawasir 11991, Saudi Arabia; Corresponding author.Department of Chemistry, Prince Sattam Bin Abdulaziz University, College of Arts and Science, Wadi Al-Dawasir 11991, Saudi ArabiaDepartment of Chemistry, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal 576104, Karnataka, IndiaDepartment of Chemistry, Prince Sattam Bin Abdulaziz University, College of Arts and Science, Wadi Al-Dawasir 11991, Saudi ArabiaDepartment of Chemistry, Prince Sattam Bin Abdulaziz University, College of Arts and Science, Wadi Al-Dawasir 11991, Saudi ArabiaChloramine-T (CAT), the sodium salt of N-chloro-p-toluenesulfonamide, is a low-cost mild oxidizing agent with a wide range of uses. Most importantly, it can be used in acidic, neutral, and basic conditions. As a result, it’s been widely used in chemistry, particularly in organic synthesis and analytical chemistry. Chloramine-T acts as a source of halonium cation and nitrogen anion and thus acts as base and nucleophile. It reacts with a wide range of functional groups and carries different molecular transformations. This paper thoroughly summarises and highlights the synthetic and analytical effectiveness of CAT. This study focuses on current developments as well as some older techniques in which CAT has been employed as an oxidizing agent. This review article stretches a comprehensive profile of the CAT reagent in organic synthesis and analytical chemistry, which will be very useful for further research exploration in this field.http://www.sciencedirect.com/science/article/pii/S1319610321002210Chloramine-TOxidantCycloadditionAziridinationHalogenationHeterocycle synthesis |
| spellingShingle | Yogeesha N. Nayak Santosh L. Gaonkar Ebraheem Abdu Musad Saleh Abdullah Mohammed A.L. Dawsari Harshitha Kakul Husain Ismail Hassan Chloramine-T (N-chloro-p-toluenesulfonamide sodium salt), a versatile reagent in organic synthesis and analytical chemistry: An up to date review Journal of Saudi Chemical Society Chloramine-T Oxidant Cycloaddition Aziridination Halogenation Heterocycle synthesis |
| title | Chloramine-T (N-chloro-p-toluenesulfonamide sodium salt), a versatile reagent in organic synthesis and analytical chemistry: An up to date review |
| title_full | Chloramine-T (N-chloro-p-toluenesulfonamide sodium salt), a versatile reagent in organic synthesis and analytical chemistry: An up to date review |
| title_fullStr | Chloramine-T (N-chloro-p-toluenesulfonamide sodium salt), a versatile reagent in organic synthesis and analytical chemistry: An up to date review |
| title_full_unstemmed | Chloramine-T (N-chloro-p-toluenesulfonamide sodium salt), a versatile reagent in organic synthesis and analytical chemistry: An up to date review |
| title_short | Chloramine-T (N-chloro-p-toluenesulfonamide sodium salt), a versatile reagent in organic synthesis and analytical chemistry: An up to date review |
| title_sort | chloramine t n chloro p toluenesulfonamide sodium salt a versatile reagent in organic synthesis and analytical chemistry an up to date review |
| topic | Chloramine-T Oxidant Cycloaddition Aziridination Halogenation Heterocycle synthesis |
| url | http://www.sciencedirect.com/science/article/pii/S1319610321002210 |
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