Cold exposure reinstates NAD+ levels and attenuates hepatocellular carcinoma
Cold exposure has been historically used for medicinal purposes, but its benefits and associated mechanisms in mammalian organisms still remain unclear. Here , we explore the chemoprotective properties of cold temperature using a mouse model of hepatocellular carcinom...
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| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Shared Science Publishers OG
2024-12-01
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| Series: | Cell Stress |
| Subjects: | |
| Online Access: | http://microbialcell.com/researcharticles/2024a-grazioso-cell-stress |
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| _version_ | 1841554855770980352 |
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| author | Tatiana P Grazioso Maria del Mar Rigual Cristian Perna Eduardo J Caleiras Nabil Djouder |
| author_facet | Tatiana P Grazioso Maria del Mar Rigual Cristian Perna Eduardo J Caleiras Nabil Djouder |
| author_sort | Tatiana P Grazioso |
| collection | DOAJ |
| description | Cold
exposure has been historically used for medicinal purposes, but its benefits and associated mechanisms in mammalian organisms still remain unclear.
Here
, we explore the chemoprotective properties of cold temperature using a mouse model of hepatocellular carcinoma (HCC) that recapitulates several human features. Chronic
cold
exposure is shown to prolong lifespan in
diseased
mice, enhance liver health, and suppress the development
of aggressive HCC
, preventing hepatocellular hypertrophy, high-grade oval cell hyperplasia, liver steatosis, and aberrant hepatocyte hyperproliferation. Mechanistically,
exposure to cold temperatures reinstates NAD
+
levels in the HCC mouse model
s
that originally exhibited
low NAD
+
levels
,
a contributing
process
to the development of liver tumors. These findings uncover
the role
of cold therapy to
attenuate
HCC development
and
potentially other existing malignancies involving NAD
+
modulation. |
| format | Article |
| id | doaj-art-43c3e75fca67441ea707ef5d5661fade |
| institution | Kabale University |
| issn | 2523-0204 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Cell Stress |
| spelling | doaj-art-43c3e75fca67441ea707ef5d5661fade2025-01-08T08:44:15ZengShared Science Publishers OGCell Stress2523-02042024-12-01812513910.15698/cst2024.12.302Cold exposure reinstates NAD+ levels and attenuates hepatocellular carcinomaTatiana P Grazioso0Maria del Mar Rigual1Cristian Perna2Eduardo J Caleiras3Nabil Djouder4Growth Factors, Nutrients and Cancer Group, Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, ES28029, SpainGrowth Factors, Nutrients and Cancer Group, Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, ES28029, SpainDepartment of Pathology, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, ES28034, SpainHistopathology Core Unit, Madrid, ES-28029, SpainGrowth Factors, Nutrients and Cancer Group, Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, ES28029, SpainCold exposure has been historically used for medicinal purposes, but its benefits and associated mechanisms in mammalian organisms still remain unclear. Here , we explore the chemoprotective properties of cold temperature using a mouse model of hepatocellular carcinoma (HCC) that recapitulates several human features. Chronic cold exposure is shown to prolong lifespan in diseased mice, enhance liver health, and suppress the development of aggressive HCC , preventing hepatocellular hypertrophy, high-grade oval cell hyperplasia, liver steatosis, and aberrant hepatocyte hyperproliferation. Mechanistically, exposure to cold temperatures reinstates NAD + levels in the HCC mouse model s that originally exhibited low NAD + levels , a contributing process to the development of liver tumors. These findings uncover the role of cold therapy to attenuate HCC development and potentially other existing malignancies involving NAD + modulation.http://microbialcell.com/researcharticles/2024a-grazioso-cell-stresscold exposurehypthermianashhccnad+cell cycleg2/m |
| spellingShingle | Tatiana P Grazioso Maria del Mar Rigual Cristian Perna Eduardo J Caleiras Nabil Djouder Cold exposure reinstates NAD+ levels and attenuates hepatocellular carcinoma Cell Stress cold exposure hypthermia nash hcc nad+ cell cycle g2/m |
| title | Cold exposure reinstates NAD+ levels and attenuates hepatocellular carcinoma |
| title_full | Cold exposure reinstates NAD+ levels and attenuates hepatocellular carcinoma |
| title_fullStr | Cold exposure reinstates NAD+ levels and attenuates hepatocellular carcinoma |
| title_full_unstemmed | Cold exposure reinstates NAD+ levels and attenuates hepatocellular carcinoma |
| title_short | Cold exposure reinstates NAD+ levels and attenuates hepatocellular carcinoma |
| title_sort | cold exposure reinstates nad levels and attenuates hepatocellular carcinoma |
| topic | cold exposure hypthermia nash hcc nad+ cell cycle g2/m |
| url | http://microbialcell.com/researcharticles/2024a-grazioso-cell-stress |
| work_keys_str_mv | AT tatianapgrazioso coldexposurereinstatesnadlevelsandattenuateshepatocellularcarcinoma AT mariadelmarrigual coldexposurereinstatesnadlevelsandattenuateshepatocellularcarcinoma AT cristianperna coldexposurereinstatesnadlevelsandattenuateshepatocellularcarcinoma AT eduardojcaleiras coldexposurereinstatesnadlevelsandattenuateshepatocellularcarcinoma AT nabildjouder coldexposurereinstatesnadlevelsandattenuateshepatocellularcarcinoma |