Cold exposure reinstates NAD+ levels and attenuates hepatocellular carcinoma
Cold exposure has been historically used for medicinal purposes, but its benefits and associated mechanisms in mammalian organisms still remain unclear. Here , we explore the chemoprotective properties of cold temperature using a mouse model of hepatocellular carcinom...
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| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Shared Science Publishers OG
2024-12-01
|
| Series: | Cell Stress |
| Subjects: | |
| Online Access: | http://microbialcell.com/researcharticles/2024a-grazioso-cell-stress |
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| Summary: | Cold
exposure has been historically used for medicinal purposes, but its benefits and associated mechanisms in mammalian organisms still remain unclear.
Here
, we explore the chemoprotective properties of cold temperature using a mouse model of hepatocellular carcinoma (HCC) that recapitulates several human features. Chronic
cold
exposure is shown to prolong lifespan in
diseased
mice, enhance liver health, and suppress the development
of aggressive HCC
, preventing hepatocellular hypertrophy, high-grade oval cell hyperplasia, liver steatosis, and aberrant hepatocyte hyperproliferation. Mechanistically,
exposure to cold temperatures reinstates NAD
+
levels in the HCC mouse model
s
that originally exhibited
low NAD
+
levels
,
a contributing
process
to the development of liver tumors. These findings uncover
the role
of cold therapy to
attenuate
HCC development
and
potentially other existing malignancies involving NAD
+
modulation. |
|---|---|
| ISSN: | 2523-0204 |