Building a collaborative ecosystem across the IDeA-CTR networks in response to a public health emergency
Abstract Introduction: The urgency and scale of the COVID-19 pandemic demanded a coordinated response from public health agencies and the biomedical research community. The National COVID Cohort Collaborative (N3C) was established as a centralized enclave in 2020 to support the study of COVID-19 a...
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Cambridge University Press
2025-01-01
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| Series: | Journal of Clinical and Translational Science |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S2059866125100988/type/journal_article |
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| author | A. Jerrod Anzalone Sharon Patrick Amber Abel Brad Price Elizabeth Reisher Kent Ripplinger Mary Emmett Ronald Horswell San Chu William B. Hillegass Francisco S. Sy Brian Melancon H. Timothy Bunnell Lucio Miele Mary Helen Mays Joseph Keawe‘aimoku Kaholokula Elizabeth S. Chen Karen M. Crowley Indra Neil Sarkar Susan L. Santangelo Clifford J. Rosen Jeremy Harper David Bard William Beasley Sally L. Hodder |
| author_facet | A. Jerrod Anzalone Sharon Patrick Amber Abel Brad Price Elizabeth Reisher Kent Ripplinger Mary Emmett Ronald Horswell San Chu William B. Hillegass Francisco S. Sy Brian Melancon H. Timothy Bunnell Lucio Miele Mary Helen Mays Joseph Keawe‘aimoku Kaholokula Elizabeth S. Chen Karen M. Crowley Indra Neil Sarkar Susan L. Santangelo Clifford J. Rosen Jeremy Harper David Bard William Beasley Sally L. Hodder |
| author_sort | A. Jerrod Anzalone |
| collection | DOAJ |
| description |
Abstract
Introduction:
The urgency and scale of the COVID-19 pandemic demanded a coordinated response from public health agencies and the biomedical research community. The National COVID Cohort Collaborative (N3C) was established as a centralized enclave in 2020 to support the study of COVID-19 across the U.S. The Institutional Development Award for Clinical and Translational Research (IDeA-CTR) centers enhanced N3C’s national response by bringing representation from rural and medically underserved communities. This improved the representation of our diverse populations in the N3C Enclave and its use for research by IDeA-state investigators.
Methods:
We developed an organizational structure across the IDeA-CTRs to improve research productivity in resource-challenged areas of the U.S. This socio-technical ecosystem, informed by community input, included a governance committee and two workstreams. The operations workstream focused on data management and regulatory compliance, while the navigation, education, analysis, and training (NEAT) workstream supported educational and analytical activities for the N3C Enclave.
Results:
Our collaborative approach led to participation by 12 IDeA-CTRs, representing over 400 investigators from 23 sites. The shared governance, investigator engagement, and resource pooling enhanced research productivity and engagement with researchers across IDeA states. Participation in this IDeA-CTR N3C consortium enhanced informatics research capacity and collaboration across the IDeA-CTRs for participating networks.
Conclusions:
This collaborative model provides a roadmap and framework for future efforts among IDeA-CTRs and other academic partnerships. The socio-technical ecosystem fostered collectivism and team science, enabling the consortium to achieve far more than isolated efforts could, offering valuable insights for interdisciplinary research across geographically dispersed communities.
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| format | Article |
| id | doaj-art-43a8d35bc05d4cc1a74dc5d62a1a98fe |
| institution | Kabale University |
| issn | 2059-8661 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Clinical and Translational Science |
| spelling | doaj-art-43a8d35bc05d4cc1a74dc5d62a1a98fe2025-08-20T04:01:18ZengCambridge University PressJournal of Clinical and Translational Science2059-86612025-01-01910.1017/cts.2025.10098Building a collaborative ecosystem across the IDeA-CTR networks in response to a public health emergencyA. Jerrod Anzalone0https://orcid.org/0000-0002-3212-7845Sharon Patrick1Amber Abel2Brad Price3https://orcid.org/0000-0002-0619-3347Elizabeth Reisher4Kent Ripplinger5Mary Emmett6Ronald Horswell7San Chu8William B. Hillegass9Francisco S. Sy10Brian Melancon11H. Timothy Bunnell12Lucio Miele13https://orcid.org/0000-0002-5853-7287Mary Helen Mays14Joseph Keawe‘aimoku Kaholokula15Elizabeth S. Chen16Karen M. Crowley17Indra Neil Sarkar18Susan L. Santangelo19Clifford J. Rosen20Jeremy Harper21David Bard22William Beasley23Sally L. Hodder24University of Nebraska Medical Center, Great Plains IDeA-CTR, Omaha, NE, USAWest Virginia University, West Virginia Clinical and Translational Science Institute, Morgantown, WV, USAWest Virginia University, West Virginia Clinical and Translational Science Institute, Morgantown, WV, USAWest Virginia University, West Virginia Clinical and Translational Science Institute, Morgantown, WV, USAUniversity of Nebraska Medical Center, Great Plains IDeA-CTR, Omaha, NE, USAUniversity of North Dakota, Translational Science Engaging North Dakota Program, Grand Forks, ND, USACAMC Health System, West Virginia Clinical and Translational Science Institute, Charleston, WV, USAPennington Biomedical Research Center, Louisiana Clinical and Translational Science Center, Baton Rouge, LA, USAPennington Biomedical Research Center, Louisiana Clinical and Translational Science Center, Baton Rouge, LA, USAUniversity of Mississippi Medical Center, Mississippi Center for Clinical and Translational Research, Jackson, MS, USAUniversity of Nevada Las Vegas, Mountain West Clinical and Translational Research Infrastructure Network, Las Vegas, NV, USAPennington Biomedical Research Center, Louisiana Clinical and Translational Science Center, Baton Rouge, LA, USANemours Children’s Health, ACCEL – Delaware Center for Translational Research, Wilmington, DE, USALouisiana State University Health Sciences Center, Louisiana Clinical and Translational Science Center, New Orleans, LA, USAUniversity of Puerto Rico, the Hispanic Alliance for Clinical and Hispanic Research, San Juan, PR, USAUniversity of Hawai‘i at Mānoa, Center for Pacific Innovations, Knowledge and Opportunities, Honolulu, HI, USABrown University, Advance Rhode Island Clinical and Translational Research, Providence, RI, USABrown University, Advance Rhode Island Clinical and Translational Research, Providence, RI, USABrown University, Advance Rhode Island Clinical and Translational Research, Providence, RI, USATufts University School of Medicine, MaineHealth Institute for Research, Northern New England Clinical and Translational Research Network, Scarborough, ME, USATufts University School of Medicine, MaineHealth Institute for Research, Northern New England Clinical and Translational Research Network, Scarborough, ME, USAOwl Health Works, LLC, Indianapolis, IN, USAUniversity of Oklahoma Health Sciences, Oklahoma Shared Clinical and Translational Resources, Oklahoma City, OK, USAUniversity of Oklahoma Health Sciences, Oklahoma Shared Clinical and Translational Resources, Oklahoma City, OK, USAWest Virginia University, West Virginia Clinical and Translational Science Institute, Morgantown, WV, USA Abstract Introduction: The urgency and scale of the COVID-19 pandemic demanded a coordinated response from public health agencies and the biomedical research community. The National COVID Cohort Collaborative (N3C) was established as a centralized enclave in 2020 to support the study of COVID-19 across the U.S. The Institutional Development Award for Clinical and Translational Research (IDeA-CTR) centers enhanced N3C’s national response by bringing representation from rural and medically underserved communities. This improved the representation of our diverse populations in the N3C Enclave and its use for research by IDeA-state investigators. Methods: We developed an organizational structure across the IDeA-CTRs to improve research productivity in resource-challenged areas of the U.S. This socio-technical ecosystem, informed by community input, included a governance committee and two workstreams. The operations workstream focused on data management and regulatory compliance, while the navigation, education, analysis, and training (NEAT) workstream supported educational and analytical activities for the N3C Enclave. Results: Our collaborative approach led to participation by 12 IDeA-CTRs, representing over 400 investigators from 23 sites. The shared governance, investigator engagement, and resource pooling enhanced research productivity and engagement with researchers across IDeA states. Participation in this IDeA-CTR N3C consortium enhanced informatics research capacity and collaboration across the IDeA-CTRs for participating networks. Conclusions: This collaborative model provides a roadmap and framework for future efforts among IDeA-CTRs and other academic partnerships. The socio-technical ecosystem fostered collectivism and team science, enabling the consortium to achieve far more than isolated efforts could, offering valuable insights for interdisciplinary research across geographically dispersed communities. https://www.cambridge.org/core/product/identifier/S2059866125100988/type/journal_articleIDeA-CTRteam sciencecollaborative analyticsnational COVID cohort collaborative (N3C)COVID-19socio-technical ecosystem |
| spellingShingle | A. Jerrod Anzalone Sharon Patrick Amber Abel Brad Price Elizabeth Reisher Kent Ripplinger Mary Emmett Ronald Horswell San Chu William B. Hillegass Francisco S. Sy Brian Melancon H. Timothy Bunnell Lucio Miele Mary Helen Mays Joseph Keawe‘aimoku Kaholokula Elizabeth S. Chen Karen M. Crowley Indra Neil Sarkar Susan L. Santangelo Clifford J. Rosen Jeremy Harper David Bard William Beasley Sally L. Hodder Building a collaborative ecosystem across the IDeA-CTR networks in response to a public health emergency Journal of Clinical and Translational Science IDeA-CTR team science collaborative analytics national COVID cohort collaborative (N3C) COVID-19 socio-technical ecosystem |
| title | Building a collaborative ecosystem across the IDeA-CTR networks in response to a public health emergency |
| title_full | Building a collaborative ecosystem across the IDeA-CTR networks in response to a public health emergency |
| title_fullStr | Building a collaborative ecosystem across the IDeA-CTR networks in response to a public health emergency |
| title_full_unstemmed | Building a collaborative ecosystem across the IDeA-CTR networks in response to a public health emergency |
| title_short | Building a collaborative ecosystem across the IDeA-CTR networks in response to a public health emergency |
| title_sort | building a collaborative ecosystem across the idea ctr networks in response to a public health emergency |
| topic | IDeA-CTR team science collaborative analytics national COVID cohort collaborative (N3C) COVID-19 socio-technical ecosystem |
| url | https://www.cambridge.org/core/product/identifier/S2059866125100988/type/journal_article |
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