Vagus nerve stimulation inhibits pyroptosis and improves outcome of cerebral ischemic stroke by upregulating osteopontin (SPP1) to disturb ASC oligomerization

Vagus nerve stimulation inhibits pyroptosis and improves outcome of cerebral ischemic stroke by upregulating osteopontin (SPP1) to disturb ASC oligomerization

Abstract Background Vagus nerve stimulation (VNS) brings new hope for handling stroke. Our previous study confirmed that VNS could reduce neuronal pyroptosis and improve stroke prognosis. However, how VNS suppresses pyroptosis remains poorly understood. Osteopontin (OPN,SPP1) plays a neuroprotective...

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Bibliographic Details
Main Authors: Jun Wen, Hao Tang, Ling Wang, Qinghuan Yang, Yong Zhao, Yu Ren, Ting Qin, Xuemei Li, Jianfeng Xu, Gongwei Jia, Qin Yang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Medicine
Subjects:
Ischemic stroke
Vagus nerve stimulation
Osteopontin
Pyroptosis
ASC
Online Access:https://doi.org/10.1186/s12916-025-04242-4
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