Bone‐Targeted Fluoropeptide Nanoparticle Inhibits NF‐κB Signaling to Treat Osteosarcoma and Tumor‐Induced Bone Destruction

Bone‐Targeted Fluoropeptide Nanoparticle Inhibits NF‐κB Signaling to Treat Osteosarcoma and Tumor‐Induced Bone Destruction

Abstract Osteosarcoma is a malignant bone cancer usually characterized by symptoms of bone loss due to pathologically enhanced osteoclast activity. Activated osteoclasts enhance bone resorption and promote osteosarcoma cell progression by secreting various cytokines. Intercepting the detrimental int...

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Bibliographic Details
Main Authors: Lin Li, Guangyu Rong, Xin Gao, Yiyun Cheng, Zhengwang Sun, Xiaopan Cai, Jianru Xiao
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Advanced Science
Subjects:
fluorination
fluoropeptide
intracellular peptide delivery
osteosarcoma
targeted nanoparticles
Online Access:https://doi.org/10.1002/advs.202412014
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