Emotional and Motivational Pain Processing: Current State of Knowledge and Perspectives in Translational Research
Pain elicits fear and anxiety and promotes escape, avoidance, and adaptive behaviors that are essential for survival. When pain persists, motivational priority and attention shift to pain-related information. Such a shift often results in impaired functionality, leading to maladaptive pain-related f...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Pain Research and Management |
| Online Access: | http://dx.doi.org/10.1155/2018/5457870 |
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| _version_ | 1841524449784889344 |
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| author | Susanne Becker Edita Navratilova Frauke Nees Stefaan Van Damme |
| author_facet | Susanne Becker Edita Navratilova Frauke Nees Stefaan Van Damme |
| author_sort | Susanne Becker |
| collection | DOAJ |
| description | Pain elicits fear and anxiety and promotes escape, avoidance, and adaptive behaviors that are essential for survival. When pain persists, motivational priority and attention shift to pain-related information. Such a shift often results in impaired functionality, leading to maladaptive pain-related fear and anxiety and escape and avoidance behaviors. Neuroimaging studies in chronic pain patients have established that brain activity, especially in cortical and mesolimbic regions, is different from activity observed during acute pain in control subjects. In this review, we discuss the psychophysiological and neuronal factors that may be associated with the transition to chronic pain. We review information from human studies on neural circuits involved in emotional and motivational pain processing and how these circuits are altered in chronic pain conditions. We then highlight findings from animal research that can increase our understanding of the molecular and cellular mechanisms underlying emotional-motivational pain processing in the brain. Finally, we discuss how translational approaches incorporating results from both human and animal investigations may aid in accelerating the discovery of therapies. |
| format | Article |
| id | doaj-art-4367777edd2e4a61af9aa5ee2685f5a6 |
| institution | Kabale University |
| issn | 1203-6765 1918-1523 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pain Research and Management |
| spelling | doaj-art-4367777edd2e4a61af9aa5ee2685f5a62025-02-03T05:53:12ZengWileyPain Research and Management1203-67651918-15232018-01-01201810.1155/2018/54578705457870Emotional and Motivational Pain Processing: Current State of Knowledge and Perspectives in Translational ResearchSusanne Becker0Edita Navratilova1Frauke Nees2Stefaan Van Damme3Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyDepartment of Pharmacology, University of Arizona, Tucson, AZ, USADepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyDepartment of Experimental-Clinical and Health Psychology, Ghent University, Ghent, BelgiumPain elicits fear and anxiety and promotes escape, avoidance, and adaptive behaviors that are essential for survival. When pain persists, motivational priority and attention shift to pain-related information. Such a shift often results in impaired functionality, leading to maladaptive pain-related fear and anxiety and escape and avoidance behaviors. Neuroimaging studies in chronic pain patients have established that brain activity, especially in cortical and mesolimbic regions, is different from activity observed during acute pain in control subjects. In this review, we discuss the psychophysiological and neuronal factors that may be associated with the transition to chronic pain. We review information from human studies on neural circuits involved in emotional and motivational pain processing and how these circuits are altered in chronic pain conditions. We then highlight findings from animal research that can increase our understanding of the molecular and cellular mechanisms underlying emotional-motivational pain processing in the brain. Finally, we discuss how translational approaches incorporating results from both human and animal investigations may aid in accelerating the discovery of therapies.http://dx.doi.org/10.1155/2018/5457870 |
| spellingShingle | Susanne Becker Edita Navratilova Frauke Nees Stefaan Van Damme Emotional and Motivational Pain Processing: Current State of Knowledge and Perspectives in Translational Research Pain Research and Management |
| title | Emotional and Motivational Pain Processing: Current State of Knowledge and Perspectives in Translational Research |
| title_full | Emotional and Motivational Pain Processing: Current State of Knowledge and Perspectives in Translational Research |
| title_fullStr | Emotional and Motivational Pain Processing: Current State of Knowledge and Perspectives in Translational Research |
| title_full_unstemmed | Emotional and Motivational Pain Processing: Current State of Knowledge and Perspectives in Translational Research |
| title_short | Emotional and Motivational Pain Processing: Current State of Knowledge and Perspectives in Translational Research |
| title_sort | emotional and motivational pain processing current state of knowledge and perspectives in translational research |
| url | http://dx.doi.org/10.1155/2018/5457870 |
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