A novel prognostic score of recurrence for endometrial cancer patients with staging surgery
Abstract Background Recently, there have been an increasing number of reports on the association between inflammatory markers and the prognosis of malignant tumors. However, the current inflammatory indicators have limited accuracy. We aimed to develop a new scoring system for predicting endometrial...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-12-01
|
| Series: | BMC Women's Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12905-024-03528-8 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841559132797140992 |
|---|---|
| author | Tomoka Maehana Naoki Kawahara Junya Kamibayashi Motoki Matsuoka Keita Waki Ryuji Kawaguchi Fuminori Kimura |
| author_facet | Tomoka Maehana Naoki Kawahara Junya Kamibayashi Motoki Matsuoka Keita Waki Ryuji Kawaguchi Fuminori Kimura |
| author_sort | Tomoka Maehana |
| collection | DOAJ |
| description | Abstract Background Recently, there have been an increasing number of reports on the association between inflammatory markers and the prognosis of malignant tumors. However, the current inflammatory indicators have limited accuracy. We aimed to develop a new scoring system for predicting endometrial cancer recurrence using inflammatory markers, tumor markers, and histological diagnoses. Methods Patients with primary, previously untreated, and suspected endometrial cancer who underwent surgery at the Nara Medical University Hospital between January 2007 and December 2020 were included and followed up until March 2024. Items were divided into positive and negative using scores based on cutoff values and placed into the new scoring system, the endometrial tumor-related (ETR) score. Results We found that positive postoperative histological examination of lymph node metastasis and myometrial invasion, high levels of carcinoembryonic antigen and D-dimer in preoperative blood tests, and a large difference in preoperative and postoperative white blood cell counts were significantly associated with recurrence. The sensitivity and specificity of recurrence prediction using the ETR score were not inferior to those using the International Federation of Gynecology and Obstetrics staging system, which is considered the best prognostic factor for survival. Conclusions The ETR score is a significant prognostic marker of recurrence in patients who have undergone staging surgery, with complete surgical tumor removal. |
| format | Article |
| id | doaj-art-432d4a0bc03d4aeaa73e29b0dc8e6480 |
| institution | Kabale University |
| issn | 1472-6874 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Women's Health |
| spelling | doaj-art-432d4a0bc03d4aeaa73e29b0dc8e64802025-01-05T12:44:50ZengBMCBMC Women's Health1472-68742024-12-012411910.1186/s12905-024-03528-8A novel prognostic score of recurrence for endometrial cancer patients with staging surgeryTomoka Maehana0Naoki Kawahara1Junya Kamibayashi2Motoki Matsuoka3Keita Waki4Ryuji Kawaguchi5Fuminori Kimura6Department of Obstetrics and Gynecology, Nara Medical UniversityDepartment of Obstetrics and Gynecology, Nara Medical UniversityDepartment of Obstetrics and Gynecology, Nara Medical UniversityDepartment of Obstetrics and Gynecology, Nara Medical UniversityDepartment of Obstetrics and Gynecology, Nara Medical UniversityDepartment of Obstetrics and Gynecology, Nara Medical UniversityDepartment of Obstetrics and Gynecology, Nara Medical UniversityAbstract Background Recently, there have been an increasing number of reports on the association between inflammatory markers and the prognosis of malignant tumors. However, the current inflammatory indicators have limited accuracy. We aimed to develop a new scoring system for predicting endometrial cancer recurrence using inflammatory markers, tumor markers, and histological diagnoses. Methods Patients with primary, previously untreated, and suspected endometrial cancer who underwent surgery at the Nara Medical University Hospital between January 2007 and December 2020 were included and followed up until March 2024. Items were divided into positive and negative using scores based on cutoff values and placed into the new scoring system, the endometrial tumor-related (ETR) score. Results We found that positive postoperative histological examination of lymph node metastasis and myometrial invasion, high levels of carcinoembryonic antigen and D-dimer in preoperative blood tests, and a large difference in preoperative and postoperative white blood cell counts were significantly associated with recurrence. The sensitivity and specificity of recurrence prediction using the ETR score were not inferior to those using the International Federation of Gynecology and Obstetrics staging system, which is considered the best prognostic factor for survival. Conclusions The ETR score is a significant prognostic marker of recurrence in patients who have undergone staging surgery, with complete surgical tumor removal.https://doi.org/10.1186/s12905-024-03528-8Endometrial cancerRecurrenceDisease-free survival rateETR scoreD-dimerWhite blood cell count |
| spellingShingle | Tomoka Maehana Naoki Kawahara Junya Kamibayashi Motoki Matsuoka Keita Waki Ryuji Kawaguchi Fuminori Kimura A novel prognostic score of recurrence for endometrial cancer patients with staging surgery BMC Women's Health Endometrial cancer Recurrence Disease-free survival rate ETR score D-dimer White blood cell count |
| title | A novel prognostic score of recurrence for endometrial cancer patients with staging surgery |
| title_full | A novel prognostic score of recurrence for endometrial cancer patients with staging surgery |
| title_fullStr | A novel prognostic score of recurrence for endometrial cancer patients with staging surgery |
| title_full_unstemmed | A novel prognostic score of recurrence for endometrial cancer patients with staging surgery |
| title_short | A novel prognostic score of recurrence for endometrial cancer patients with staging surgery |
| title_sort | novel prognostic score of recurrence for endometrial cancer patients with staging surgery |
| topic | Endometrial cancer Recurrence Disease-free survival rate ETR score D-dimer White blood cell count |
| url | https://doi.org/10.1186/s12905-024-03528-8 |
| work_keys_str_mv | AT tomokamaehana anovelprognosticscoreofrecurrenceforendometrialcancerpatientswithstagingsurgery AT naokikawahara anovelprognosticscoreofrecurrenceforendometrialcancerpatientswithstagingsurgery AT junyakamibayashi anovelprognosticscoreofrecurrenceforendometrialcancerpatientswithstagingsurgery AT motokimatsuoka anovelprognosticscoreofrecurrenceforendometrialcancerpatientswithstagingsurgery AT keitawaki anovelprognosticscoreofrecurrenceforendometrialcancerpatientswithstagingsurgery AT ryujikawaguchi anovelprognosticscoreofrecurrenceforendometrialcancerpatientswithstagingsurgery AT fuminorikimura anovelprognosticscoreofrecurrenceforendometrialcancerpatientswithstagingsurgery AT tomokamaehana novelprognosticscoreofrecurrenceforendometrialcancerpatientswithstagingsurgery AT naokikawahara novelprognosticscoreofrecurrenceforendometrialcancerpatientswithstagingsurgery AT junyakamibayashi novelprognosticscoreofrecurrenceforendometrialcancerpatientswithstagingsurgery AT motokimatsuoka novelprognosticscoreofrecurrenceforendometrialcancerpatientswithstagingsurgery AT keitawaki novelprognosticscoreofrecurrenceforendometrialcancerpatientswithstagingsurgery AT ryujikawaguchi novelprognosticscoreofrecurrenceforendometrialcancerpatientswithstagingsurgery AT fuminorikimura novelprognosticscoreofrecurrenceforendometrialcancerpatientswithstagingsurgery |