Improvement of osteogenic differentiation potential of placenta-derived mesenchymal stem cells by metformin via AMPK pathway activation

Improvement of osteogenic differentiation potential of placenta-derived mesenchymal stem cells by metformin via AMPK pathway activation

Abstract Background Placenta-derived human mesenchymal stem cells (PL-MSCs) have gained a lot of attention in the field of regenerative medicine due to their availability and bone-forming capacity. However, the osteogenic differentiation capacity of these cells remains inconsistent and could be impr...

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Bibliographic Details
Main Authors: Sirikul Manochantr, Ladda Meesuk, Nuengruethai Chadee, Jintamai Suwanprateeb, Chairat Tantrawatpan, Pakpoom Kheolamai
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Stem Cell Research & Therapy
Subjects:
Metformin
Mesenchymal stem cells
Osteogenic differentiation
Diabetes mellitus
Online Access:https://doi.org/10.1186/s13287-024-04014-6
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