Cepharanthine as an effective small cell lung cancer inhibitor: integrated insights from network pharmacology, RNA sequencing, and experimental validation

Cepharanthine as an effective small cell lung cancer inhibitor: integrated insights from network pharmacology, RNA sequencing, and experimental validation

BackgroundSmall cell lung cancer (SCLC) is an aggressive malignancy with limited treatment options and poor prognosis, underscoring the need for new therapeutic agents.MethodsA library of 640 natural products was screened for anti-proliferative activity in SCLC cells. The effects of Cepharanthine (C...

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Bibliographic Details
Main Authors: Fengyun Zhao, Zhaowei Ding, Mengting Chen, Mingfang Ji, Fugui Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Pharmacology
Subjects:
small cell lung cancer
cepharanthine
network pharmacology
cholesterol metabolism
RNA sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1517386/full
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