Integrative bioinformatics approach identifies novel drug targets for hyperaldosteronism, with a focus on SHMT1 as a promising therapeutic candidate

Integrative bioinformatics approach identifies novel drug targets for hyperaldosteronism, with a focus on SHMT1 as a promising therapeutic candidate

Abstract Primary aldosteronism (PA), characterized by autonomous aldosterone overproduction, is a major cause of secondary hypertension with significant cardiovascular complications. Current treatments mainly focus on symptom management rather than addressing underlying mechanisms. This study aims t...

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Bibliographic Details
Main Authors: Minyue Jia, Liya Lin, Hanxiao Yu, Zhichao Dong, Xin Pan, Xiaoxiao Song
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Hyperaldosteronism
TWAS
GWAS
QTL
Mendelian randomization
SHMT1
Online Access:https://doi.org/10.1038/s41598-025-85900-8
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