TNF inhibitors target a mevalonate metabolite/TRPM2/calcium signaling axis in neutrophils to dampen vasculitis in Behçet’s disease

TNF inhibitors target a mevalonate metabolite/TRPM2/calcium signaling axis in neutrophils to dampen vasculitis in Behçet’s disease

Abstract TNF inhibitors have been used to treat autoimmune and autoinflammatory diseases. Here we report an unexpected mechanism underlying the therapeutic effects of TNF inhibitors in Behçet’s disease (BD), an autoimmune inflammatory disorder. Using serum metabolomics and peripheral immunocyte tran...

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Bibliographic Details
Main Authors: Menghao Zhang, Na Kang, Xin Yu, Xiaoyang Zhang, Qinghui Duan, Xianqiang Ma, Qiancheng Zhao, Zhimian Wang, Xiao’ou Wang, Yeling Liu, Yuxiao Zhang, Can Zhu, Ruiyu Gao, Xin Min, Cuifeng Li, Jin Jin, Qian Cao, Rongbei Liu, Xiaoyin Bai, Hong Yang, Lidan Zhao, Jinjing Liu, Hua Chen, Yonghui Zhang, Wanli Liu, Wenjie Zheng
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-53528-3
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