Physiological oxygen concentration during sympathetic primary neuron culture improves neuronal health and reduces HSV-1 reactivation

Physiological oxygen concentration during sympathetic primary neuron culture improves neuronal health and reduces HSV-1 reactivation

ABSTRACT Herpes simplex virus-1 (HSV-1) establishes a latent infection in peripheral neurons and periodically reactivates in response to a stimulus to permit transmission. In vitro models using primary neurons are invaluable to studying latent infection because they use bona fide neurons that have u...

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Bibliographic Details
Main Authors: Sara A. Dochnal, Patryk A. Krakowiak, Abigail L. Whitford, Anna R. Cliffe
Format: Article
Language:English
Published: American Society for Microbiology 2024-12-01
Series:Microbiology Spectrum
Subjects:
herpes simplex virus
oxygen
in vitro culture
latency
reactivation
sympathetic neurons
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02031-24
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