Two‐pronged reversal of chemotherapy resistance by gold nanorods induced mild photothermal effect
Abstract Chemotherapy treatment outcomes are severely restricted by multidrug resistance (MDR), in which tumors develop a multiple cross‐resistance toward drug involving the pump and nonpump resistance mechanisms, resulting in drug efflux and defending against drug toxicity. Herein, we constructed a...
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| Format: | Article |
| Language: | English |
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Wiley
2024-09-01
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| Series: | Bioengineering & Translational Medicine |
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| Online Access: | https://doi.org/10.1002/btm2.10670 |
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| author | Qi Shang Ziyan Chen Jing Li Mingmei Guo Jiapei Yang Zhu Jin Yuanyuan Shen Shengrong Guo Feihu Wang |
| author_facet | Qi Shang Ziyan Chen Jing Li Mingmei Guo Jiapei Yang Zhu Jin Yuanyuan Shen Shengrong Guo Feihu Wang |
| author_sort | Qi Shang |
| collection | DOAJ |
| description | Abstract Chemotherapy treatment outcomes are severely restricted by multidrug resistance (MDR), in which tumors develop a multiple cross‐resistance toward drug involving the pump and nonpump resistance mechanisms, resulting in drug efflux and defending against drug toxicity. Herein, we constructed a pH and near infrared (NIR) light responsive nanomedicine DOX@FG based on gold nanorods (GNRs) that demonstrated the potential to improve chemotherapy outcomes by overcoming MDR. DOX@FG was constructed by conjugating folic acid (FA) and doxorubicin (DOX) derivatives onto GNRs, where the DOX derivatives possessed an acid‐labile hydrazone bond. Stimulated by the acidic media in endocytic organelles, DOX@FG exhibited a responsive dissociation for the controlled release of chemotherapeutic DOX. Surprisingly, we found the mild photothermal effect elicited by GNRs under NIR irradiation simultaneously inhibited the pump and nonpump resistance mechanisms, enhancing the intracellular DOX accumulation and sensitizing the cancer cells to DOX, collectively amplify the chemotherapy efficacy and delay the MCF‐7/ADR breast tumor growth. This intelligent DOX@FG nanomedicine with the potential for two‐pronged reversal of MDR may provide a prospective way to encourage chemotherapy efficacy. |
| format | Article |
| id | doaj-art-42cd3a381a414d0abd33fbb097c06cee |
| institution | Kabale University |
| issn | 2380-6761 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioengineering & Translational Medicine |
| spelling | doaj-art-42cd3a381a414d0abd33fbb097c06cee2024-11-14T12:22:22ZengWileyBioengineering & Translational Medicine2380-67612024-09-0195n/an/a10.1002/btm2.10670Two‐pronged reversal of chemotherapy resistance by gold nanorods induced mild photothermal effectQi Shang0Ziyan Chen1Jing Li2Mingmei Guo3Jiapei Yang4Zhu Jin5Yuanyuan Shen6Shengrong Guo7Feihu Wang8School of Biomedical Engineering, Shanghai Jiao Tong University Shanghai People's Republic of ChinaSchool of Pharmacy, Shanghai Jiao Tong University Shanghai People's Republic of ChinaDepartment of Pharmacy Putuo People's Hospital Shanghai People's Republic of ChinaSchool of Biomedical Engineering, Shanghai Jiao Tong University Shanghai People's Republic of ChinaSchool of Biomedical Engineering, Shanghai Jiao Tong University Shanghai People's Republic of ChinaSchool of Pharmacy, Shanghai Jiao Tong University Shanghai People's Republic of ChinaSchool of Pharmacy, Shanghai Jiao Tong University Shanghai People's Republic of ChinaSchool of Pharmacy, Shanghai Jiao Tong University Shanghai People's Republic of ChinaSchool of Biomedical Engineering, Shanghai Jiao Tong University Shanghai People's Republic of ChinaAbstract Chemotherapy treatment outcomes are severely restricted by multidrug resistance (MDR), in which tumors develop a multiple cross‐resistance toward drug involving the pump and nonpump resistance mechanisms, resulting in drug efflux and defending against drug toxicity. Herein, we constructed a pH and near infrared (NIR) light responsive nanomedicine DOX@FG based on gold nanorods (GNRs) that demonstrated the potential to improve chemotherapy outcomes by overcoming MDR. DOX@FG was constructed by conjugating folic acid (FA) and doxorubicin (DOX) derivatives onto GNRs, where the DOX derivatives possessed an acid‐labile hydrazone bond. Stimulated by the acidic media in endocytic organelles, DOX@FG exhibited a responsive dissociation for the controlled release of chemotherapeutic DOX. Surprisingly, we found the mild photothermal effect elicited by GNRs under NIR irradiation simultaneously inhibited the pump and nonpump resistance mechanisms, enhancing the intracellular DOX accumulation and sensitizing the cancer cells to DOX, collectively amplify the chemotherapy efficacy and delay the MCF‐7/ADR breast tumor growth. This intelligent DOX@FG nanomedicine with the potential for two‐pronged reversal of MDR may provide a prospective way to encourage chemotherapy efficacy.https://doi.org/10.1002/btm2.10670chemotherapygold nanorodsmultidrug resistanceNIR irradiationphotothermal effect |
| spellingShingle | Qi Shang Ziyan Chen Jing Li Mingmei Guo Jiapei Yang Zhu Jin Yuanyuan Shen Shengrong Guo Feihu Wang Two‐pronged reversal of chemotherapy resistance by gold nanorods induced mild photothermal effect Bioengineering & Translational Medicine chemotherapy gold nanorods multidrug resistance NIR irradiation photothermal effect |
| title | Two‐pronged reversal of chemotherapy resistance by gold nanorods induced mild photothermal effect |
| title_full | Two‐pronged reversal of chemotherapy resistance by gold nanorods induced mild photothermal effect |
| title_fullStr | Two‐pronged reversal of chemotherapy resistance by gold nanorods induced mild photothermal effect |
| title_full_unstemmed | Two‐pronged reversal of chemotherapy resistance by gold nanorods induced mild photothermal effect |
| title_short | Two‐pronged reversal of chemotherapy resistance by gold nanorods induced mild photothermal effect |
| title_sort | two pronged reversal of chemotherapy resistance by gold nanorods induced mild photothermal effect |
| topic | chemotherapy gold nanorods multidrug resistance NIR irradiation photothermal effect |
| url | https://doi.org/10.1002/btm2.10670 |
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