Construction of a macrophage-related prognostic signature and assessment of immune checkpoint inhibitor efficacy of HCC

Construction of a macrophage-related prognostic signature and assessment of immune checkpoint inhibitor efficacy of HCC

Abstract Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death, with limited treatment options and high recurrence rates. Prognostic biomarkers and predictors of immune checkpoint inhibitor (ICI) response are urgently needed. This study aimed to develop a macrophage-related gene...

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Bibliographic Details
Main Authors: Shouge Zang, Hongwei Chen, Yuqian Han, Di Cui, Jiangtao Yu
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Hepatocellular carcinoma
Tumor-associated macrophages
Single-cell sequencing
Immune checkpoint inhibitors
Prognostic signature
PLAUR
Online Access:https://doi.org/10.1038/s41598-025-06937-3
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