From geriatric assessment to inflammation. A pilot, observational, study about frailty components in older patients with persistent atrial fibrillation
Background: Atrial fibrillation (AF) is the most common arrhythmia diagnosed at an older age. AF is associated with frailty, a condition possibly justifying the higher rate of complications and mortality in aged individuals. This study was aimed at describing the characteristics correlated to frailt...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | International Journal of Cardiology: Heart & Vasculature |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352906724002240 |
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| author | Stefano Fumagalli Giulia Ricciardi Claudia Di Serio Elisa Berni Giancarlo La Marca Giuseppe Pieraccini Riccardo Romoli Emanuele Santamaria Giulia Spanalatte Camilla Cagnoni Arianna Tariello Giada Alla Viligiardi Agostino Virdis Igor Diemberger Andrea Ungar Niccolò Marchionni |
| author_facet | Stefano Fumagalli Giulia Ricciardi Claudia Di Serio Elisa Berni Giancarlo La Marca Giuseppe Pieraccini Riccardo Romoli Emanuele Santamaria Giulia Spanalatte Camilla Cagnoni Arianna Tariello Giada Alla Viligiardi Agostino Virdis Igor Diemberger Andrea Ungar Niccolò Marchionni |
| author_sort | Stefano Fumagalli |
| collection | DOAJ |
| description | Background: Atrial fibrillation (AF) is the most common arrhythmia diagnosed at an older age. AF is associated with frailty, a condition possibly justifying the higher rate of complications and mortality in aged individuals. This study was aimed at describing the characteristics correlated to frailty in older AF subjects. Methods: After having excluded a < 3 months major surgery procedure, cancer or other conditions associated with activation of inflammation, and a life expectancy < 12 months, we consecutively enrolled patients ≥ 65 years with persistent AF. They underwent a Comprehensive Geriatric Assessment evaluation. In particular, Mini-Mental State Examination, 15-item Geriatric Depression Scale and Short-Physical Performance Battery (SPPB) described, respectively, cognitive profile, depressive symptoms and physical performance. A venous blood sample was collected to measure interleukin-6 (IL-6; marker of low-grade inflammation) and acylcarnitines, expression of mitochondrial dysfunction and abnormal energy production. Results: Overall, 49 patients (mean age: 76 ± 6 years; women 30.6 %) were studied. Cluster analysis described two different patterns; the second (N = 18, 36.7 %), when compared to the first one (N = 31, 63.3 %), was characterized by a worse phenotype, identified by the simultaneous presence of lower body mass index, higher CHA2DS2-VASc score (index of clinical complexity), worse SPPB functional performance, and high IL-6 levels. Second cluster patients had a higher concentration of 13 of the 35 acylcarnitines evaluated and increased 5-year mortality. All these features can outline a frail condition. Conclusions: Body size, clinical complexity, physical performance and low-grade inflammation seem to rapidly and adequately describe frailty. |
| format | Article |
| id | doaj-art-42c24ed07e2f4a35af7dbe306da13c20 |
| institution | Kabale University |
| issn | 2352-9067 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology: Heart & Vasculature |
| spelling | doaj-art-42c24ed07e2f4a35af7dbe306da13c202024-11-29T06:24:29ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672024-12-0155101558From geriatric assessment to inflammation. A pilot, observational, study about frailty components in older patients with persistent atrial fibrillationStefano Fumagalli0Giulia Ricciardi1Claudia Di Serio2Elisa Berni3Giancarlo La Marca4Giuseppe Pieraccini5Riccardo Romoli6Emanuele Santamaria7Giulia Spanalatte8Camilla Cagnoni9Arianna Tariello10Giada Alla Viligiardi11Agostino Virdis12Igor Diemberger13Andrea Ungar14Niccolò Marchionni15Department of Experimental and Clinical Medicine, Geriatric Intensive Care Unit, University of Florence and AOU Careggi, Florence, Italy; Corresponding author at: Department of Experimental and Clinical Medicine, Geriatric Intensive Care Unit, University of Florence and AOU Careggi, Viale Pieraccini 6, 50139 Florence, Italy.Department of Experimental and Clinical Medicine, Geriatric Intensive Care Unit, University of Florence and AOU Careggi, Florence, ItalyDepartment of Experimental and Clinical Medicine, Geriatric Intensive Care Unit, University of Florence and AOU Careggi, Florence, ItalyDepartment of Experimental and Clinical Medicine, Geriatric Intensive Care Unit, University of Florence and AOU Careggi, Florence, ItalyMass Spectrometry Centre (CISM), University of Florence, Florence, Italy; Newborn Screening, Clinical Chemistry and Pharmacology Lab, Meyer Children’s Hospital IRCCS, Florence, ItalyMass Spectrometry Centre (CISM), University of Florence, Florence, ItalyMass Spectrometry Centre (CISM), University of Florence, Florence, ItalyDepartment of Experimental and Clinical Medicine, Geriatric Intensive Care Unit, University of Florence and AOU Careggi, Florence, ItalyDepartment of Experimental and Clinical Medicine, Geriatric Intensive Care Unit, University of Florence and AOU Careggi, Florence, ItalyDepartment of Experimental and Clinical Medicine, Geriatric Intensive Care Unit, University of Florence and AOU Careggi, Florence, ItalyDepartment of Experimental and Clinical Medicine, Geriatric Intensive Care Unit, University of Florence and AOU Careggi, Florence, ItalyDepartment of Experimental and Clinical Medicine, Geriatric Intensive Care Unit, University of Florence and AOU Careggi, Florence, ItalyGeriatrics Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, ItalyDepartment of Medical and Surgical Sciences, DIMEC, University of Bologna, Bologna, Italy; Cardiology Unit, IRCCS Policlinico di S. Orsola, Bologna, ItalyDepartment of Experimental and Clinical Medicine, Geriatric Intensive Care Unit, University of Florence and AOU Careggi, Florence, ItalyDepartment of Experimental and Clinical Medicine, Geriatric Intensive Care Unit, University of Florence and AOU Careggi, Florence, ItalyBackground: Atrial fibrillation (AF) is the most common arrhythmia diagnosed at an older age. AF is associated with frailty, a condition possibly justifying the higher rate of complications and mortality in aged individuals. This study was aimed at describing the characteristics correlated to frailty in older AF subjects. Methods: After having excluded a < 3 months major surgery procedure, cancer or other conditions associated with activation of inflammation, and a life expectancy < 12 months, we consecutively enrolled patients ≥ 65 years with persistent AF. They underwent a Comprehensive Geriatric Assessment evaluation. In particular, Mini-Mental State Examination, 15-item Geriatric Depression Scale and Short-Physical Performance Battery (SPPB) described, respectively, cognitive profile, depressive symptoms and physical performance. A venous blood sample was collected to measure interleukin-6 (IL-6; marker of low-grade inflammation) and acylcarnitines, expression of mitochondrial dysfunction and abnormal energy production. Results: Overall, 49 patients (mean age: 76 ± 6 years; women 30.6 %) were studied. Cluster analysis described two different patterns; the second (N = 18, 36.7 %), when compared to the first one (N = 31, 63.3 %), was characterized by a worse phenotype, identified by the simultaneous presence of lower body mass index, higher CHA2DS2-VASc score (index of clinical complexity), worse SPPB functional performance, and high IL-6 levels. Second cluster patients had a higher concentration of 13 of the 35 acylcarnitines evaluated and increased 5-year mortality. All these features can outline a frail condition. Conclusions: Body size, clinical complexity, physical performance and low-grade inflammation seem to rapidly and adequately describe frailty.http://www.sciencedirect.com/science/article/pii/S2352906724002240Atrial fibrillationFrailtyOlder patientsInflammationPhysical performanceAcylcarnitines |
| spellingShingle | Stefano Fumagalli Giulia Ricciardi Claudia Di Serio Elisa Berni Giancarlo La Marca Giuseppe Pieraccini Riccardo Romoli Emanuele Santamaria Giulia Spanalatte Camilla Cagnoni Arianna Tariello Giada Alla Viligiardi Agostino Virdis Igor Diemberger Andrea Ungar Niccolò Marchionni From geriatric assessment to inflammation. A pilot, observational, study about frailty components in older patients with persistent atrial fibrillation International Journal of Cardiology: Heart & Vasculature Atrial fibrillation Frailty Older patients Inflammation Physical performance Acylcarnitines |
| title | From geriatric assessment to inflammation. A pilot, observational, study about frailty components in older patients with persistent atrial fibrillation |
| title_full | From geriatric assessment to inflammation. A pilot, observational, study about frailty components in older patients with persistent atrial fibrillation |
| title_fullStr | From geriatric assessment to inflammation. A pilot, observational, study about frailty components in older patients with persistent atrial fibrillation |
| title_full_unstemmed | From geriatric assessment to inflammation. A pilot, observational, study about frailty components in older patients with persistent atrial fibrillation |
| title_short | From geriatric assessment to inflammation. A pilot, observational, study about frailty components in older patients with persistent atrial fibrillation |
| title_sort | from geriatric assessment to inflammation a pilot observational study about frailty components in older patients with persistent atrial fibrillation |
| topic | Atrial fibrillation Frailty Older patients Inflammation Physical performance Acylcarnitines |
| url | http://www.sciencedirect.com/science/article/pii/S2352906724002240 |
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