Study on the efficacy of fractional CO2 laser treatment for vaginal relaxation syndrome combined with recurrent bacterial vaginitis
Abstract To investigate the efficacy and mechanisms of fractional CO2 laser treatment for Vaginal Relaxation Syndrome (VRS) combined with recurrent bacterial vaginitis. Patients with VRS and recurrent bacterial vaginitis were randomly assigned to an intervention group (n = 60) receiving fractional C...
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-85661-4 |
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| author | Lan Wang Lulu Chen Yanhui Li Xinnan Song Jiaya Mo Guoyan Ding Ying Shen |
| author_facet | Lan Wang Lulu Chen Yanhui Li Xinnan Song Jiaya Mo Guoyan Ding Ying Shen |
| author_sort | Lan Wang |
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| description | Abstract To investigate the efficacy and mechanisms of fractional CO2 laser treatment for Vaginal Relaxation Syndrome (VRS) combined with recurrent bacterial vaginitis. Patients with VRS and recurrent bacterial vaginitis were randomly assigned to an intervention group (n = 60) receiving fractional CO2 laser therapy in addition to metronidazole, or a control group (n = 60) receiving metronidazole alone. Post-treatment assessments included vaginal relaxation, vaginal health index (VHI) scores, lactobacilli distribution, vaginal pH, recurrence rates, and the correlation between lactobacilli distribution and VHI. (1) Vaginal relaxation improved significantly in the intervention group compared to both pre-treatment and the control group (P = 0.000). (2) VHI scores and lactobacilli distribution improved in both groups post-treatment, with significantly higher scores in the intervention group (P = 0.000). (3) The intervention group exhibited a significantly lower vaginal pH compared to pre-treatment and the control group (P = 0.001). (4) Recurrence rates were significantly lower in the intervention group (8.33%) compared to the control group (36.67%) (P = 0.000). A strong positive correlation was found between lactobacilli distribution and VHI in the intervention group (r = 0.79, P < 0.001). Fractional CO2 laser combined with conventional therapy improves VRS and recurrent bacterial vaginitis outcomes, reduces recurrence, and enhances vaginal microecology. Trial registration: Chinese Clinical Trial Registry, Registration number ChiCTR2400094125. |
| format | Article |
| id | doaj-art-42154c316ca3427d9410f804491623a5 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-42154c316ca3427d9410f804491623a52025-01-12T12:17:23ZengNature PortfolioScientific Reports2045-23222025-01-011511710.1038/s41598-025-85661-4Study on the efficacy of fractional CO2 laser treatment for vaginal relaxation syndrome combined with recurrent bacterial vaginitisLan Wang0Lulu Chen1Yanhui Li2Xinnan Song3Jiaya Mo4Guoyan Ding5Ying Shen6Department of Gynecology, Guilin People’s HospitalGraduate School, Chongqing Medical UniversityDepartment of Gynecology, The First People’s Hospital of YulinDepartment of Anesthesiology, Guilin People’s HospitalDepartment of Gynecology, Guilin People’s HospitalDepartment of Clinical Laboratory, Guilin People’s HospitalDepartment of Gynecology, Guilin People’s HospitalAbstract To investigate the efficacy and mechanisms of fractional CO2 laser treatment for Vaginal Relaxation Syndrome (VRS) combined with recurrent bacterial vaginitis. Patients with VRS and recurrent bacterial vaginitis were randomly assigned to an intervention group (n = 60) receiving fractional CO2 laser therapy in addition to metronidazole, or a control group (n = 60) receiving metronidazole alone. Post-treatment assessments included vaginal relaxation, vaginal health index (VHI) scores, lactobacilli distribution, vaginal pH, recurrence rates, and the correlation between lactobacilli distribution and VHI. (1) Vaginal relaxation improved significantly in the intervention group compared to both pre-treatment and the control group (P = 0.000). (2) VHI scores and lactobacilli distribution improved in both groups post-treatment, with significantly higher scores in the intervention group (P = 0.000). (3) The intervention group exhibited a significantly lower vaginal pH compared to pre-treatment and the control group (P = 0.001). (4) Recurrence rates were significantly lower in the intervention group (8.33%) compared to the control group (36.67%) (P = 0.000). A strong positive correlation was found between lactobacilli distribution and VHI in the intervention group (r = 0.79, P < 0.001). Fractional CO2 laser combined with conventional therapy improves VRS and recurrent bacterial vaginitis outcomes, reduces recurrence, and enhances vaginal microecology. Trial registration: Chinese Clinical Trial Registry, Registration number ChiCTR2400094125.https://doi.org/10.1038/s41598-025-85661-4Fractional CO2 laserVaginal relaxation syndromeBacterial vaginitisRecurrent |
| spellingShingle | Lan Wang Lulu Chen Yanhui Li Xinnan Song Jiaya Mo Guoyan Ding Ying Shen Study on the efficacy of fractional CO2 laser treatment for vaginal relaxation syndrome combined with recurrent bacterial vaginitis Scientific Reports Fractional CO2 laser Vaginal relaxation syndrome Bacterial vaginitis Recurrent |
| title | Study on the efficacy of fractional CO2 laser treatment for vaginal relaxation syndrome combined with recurrent bacterial vaginitis |
| title_full | Study on the efficacy of fractional CO2 laser treatment for vaginal relaxation syndrome combined with recurrent bacterial vaginitis |
| title_fullStr | Study on the efficacy of fractional CO2 laser treatment for vaginal relaxation syndrome combined with recurrent bacterial vaginitis |
| title_full_unstemmed | Study on the efficacy of fractional CO2 laser treatment for vaginal relaxation syndrome combined with recurrent bacterial vaginitis |
| title_short | Study on the efficacy of fractional CO2 laser treatment for vaginal relaxation syndrome combined with recurrent bacterial vaginitis |
| title_sort | study on the efficacy of fractional co2 laser treatment for vaginal relaxation syndrome combined with recurrent bacterial vaginitis |
| topic | Fractional CO2 laser Vaginal relaxation syndrome Bacterial vaginitis Recurrent |
| url | https://doi.org/10.1038/s41598-025-85661-4 |
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