Spatial transcriptomic analysis deciphers adipocyte-to-fibroblast transformation in bleomycin-induced murine skin fibrosis

Spatial transcriptomic analysis deciphers adipocyte-to-fibroblast transformation in bleomycin-induced murine skin fibrosis

Abstract. Background:. Scleroderma is characterized by inflammation and fibrosis, predominantly occurring in the skin and extending to various parts of the body. The pathophysiology of scleroderma is multifaceted, with the current understanding including endothelial damage, inflammatory cell infilt...

Full description

Saved in:

Bibliographic Details
Main Authors:	Yixiang Zhang, Jiahao He, Fangzhou Xie, Shengzhou Shan, Jiaqi Qin, Chuandong Wang, Qingfeng Li, Yun Xie, Bin Fang, Lishao Guo
Format:	Article
Language:	English
Published:	Wolters Kluwer 2024-11-01
Series:	Chinese Medical Journal
Online Access:	http://journals.lww.com/10.1097/CM9.0000000000003219
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Comparative Study of Ectopic Lymphoid Aggregates in Sheep and Murine Models of Bleomycin-Induced Pulmonary Fibrosis
by: Udari Eshani Perera, et al.
Published: (2023-01-01)

Chlorogenic Acid Alleviates Inflammation and Fibrosis in a Murine Model of Bleomycin-Induced Systemic Sclerosis: A Histological Analysis
by: Juan Manuel Velázquez-Enríquez, et al.
Published: (2024-11-01)

Bleomycin pollution and lung health: The therapeutic potential of peimine in bleomycin-induced pulmonary fibrosis by inhibiting glycolysis
by: Kangchen Li, et al.
Published: (2025-01-01)

Inhalation of itraconazole mitigates bleomycin-induced lung fibrosis via regulating SPP1 and C3 signaling pathway pivotal in the interaction between phagocytic macrophages and diseased fibroblasts
by: Caizhe Pan, et al.
Published: (2024-11-01)

Anti-Inflammatory Effects of Aptamin C in Pulmonary Fibrosis Induced by Bleomycin
by: Seulgi Shin, et al.
Published: (2024-11-01)

A Chinese Traditional Therapy for Bleomycin-Induced Pulmonary Fibrosis in Mice
by: Lifang Sun, et al.
Published: (2018-01-01)

Dietary Flaxseed Oil Protects against Bleomycin-Induced Pulmonary Fibrosis in Rats
by: Joshua Lawrenz, et al.
Published: (2012-01-01)

The Protective Effect of Naringin against Bleomycin-Induced Pulmonary Fibrosis in Wistar Rats
by: Nergiz H. Turgut, et al.
Published: (2016-01-01)

THE PPARG RECEPTOR AGONIST PIOGLITAZONE REDUCES PULMONARY FIBROSIS INDUCED BY BLEOMYCIN ADMINISTRATION IN MICE
by: A.V. Kabaliei, et al.
Published: (2024-12-01)

Macrophage-derived extracellular vesicles transfer mitochondria to adipocytes and promote adipocyte–myofibroblast transition in epidural fibrosis
by: Feng Hua, et al.
Published: (2024-12-01)

Intervention effect and mechanism of Dracocephalum moldavica L. extract on bleomycin-induced pulmonary fibrosis in rats
by: Xiaoyu SUN, et al.
Published: (2024-12-01)

HMGB1 Box A gene therapy to alleviate bleomycin-induced pulmonary fibrosis in rats
by: Rathasapa Patarat, et al.
Published: (2025-01-01)

Optimized digital workflow for pathologist-grade evaluation in bleomycin-induced pulmonary fibrosis mouse model
by: Toshiki Goto, et al.
Published: (2025-01-01)

The Chemokine System as a Key Regulator of Pulmonary Fibrosis: Converging Pathways in Human Idiopathic Pulmonary Fibrosis (IPF) and the Bleomycin-Induced Lung Fibrosis Model in Mice
by: Remo Castro Russo, et al.
Published: (2024-12-01)

Antrodia cinnamomea extract alleviates bleomycin-induced pulmonary fibrosis in mice by inhibiting the mTOR pathway
by: Ying-Wei Lan, et al.
Published: (2024-12-01)

Morphological features of skin scars on the background of treatment with autologous adipocytes
by: І. V. Baranov, et al.
Published: (2020-10-01)

Adipocyte associated glucocorticoid signaling regulates normal fibroblast function which is lost in inflammatory arthritis
by: Heather J. Faust, et al.
Published: (2024-11-01)

Qingfei Tongluo Mixture Attenuates Bleomycin-Induced Pulmonary Inflammation and Fibrosis through mTOR-Dependent Autophagy in Rats
by: Shuyu Ge, et al.
Published: (2024-01-01)

Protective effect of essential oil of Foeniculum vulgare Mill. against bleomycin-induced pulmonary fibrosis and oxidative stress in rat
by: Marwa Khammassi, et al.
Published: (2024-11-01)

Deciphering Immune Modulation in Chickens Co-Infected with ALV-J and CIAV: A Transcriptomic Approach
by: Sheng Chen, et al.
Published: (2024-11-01)

Deciphering key nano-bio interface descriptors to predict nanoparticle-induced lung fibrosis
by: Jiayu Cao, et al.
Published: (2025-01-01)

Bleomycin, when miligrams do not refer to weight
by: Miguel Al Kassam-Martínez, et al.
Published: (2017-11-01)

Gene expression dynamics in fibroblasts during early-stage murine pancreatic carcinogenesis
by: Nupur Ohri, et al.
Published: (2025-01-01)

Rosiglitazone Induces Mitochondrial Biogenesis in Differentiated Murine 3T3-L1 and C3H/10T1/2 Adipocytes
by: James X. Rong, et al.
Published: (2011-01-01)

The Macrophage–Fibroblast Dipole in the Context of Cardiac Repair and Fibrosis
by: Stelios Psarras
Published: (2024-11-01)

Phytoreduced gold nanoparticles from vitalmelon promote white adipocyte browning in murine cells by targeting phospholipase D2
by: Sun Young Park, et al.
Published: (2025-02-01)

Regenerative Potential Nanomedicine of Adipocyte Stem Cell-Derived Exosomes in Senescent Skin Tissue
by: Li AN, et al.
Published: (2024-12-01)

Intralesional bleomycin in treatment of orbital and/or adnexal venolymphatic malformations
by: Sindhuja Murugesan, et al.
Published: (2024-12-01)

Bleomycin Sclerotherapy for Severe Symptomatic and Persistent Pelvic Lymphocele
by: Ana Sofia Fernandes, et al.
Published: (2014-01-01)

Spatial transcriptomics deciphers the immunosuppressive microenvironment in colorectal cancer with tumour thrombus
by: Heming Ge, et al.
Published: (2024-12-01)

Divergent roles of m6A in orchestrating brown and white adipocyte transcriptomes and systemic metabolism
by: Ling Xiao, et al.
Published: (2025-01-01)

TWISTed fibroblasts: New drivers of intestinal fibrosis in Crohn's disease
by: Sara Lovisa, et al.
Published: (2024-12-01)

The Roles of Skin Fibroblasts at Local Acupoints in Chrono-Acupuncture
by: Nannan Liu, et al.
Published: (2020-01-01)

Single cell transcriptomics reveals the cellular heterogeneity of keloids and the mechanism of their aggressiveness
by: Xinwei Cheng, et al.
Published: (2024-12-01)

Indigenous primary culture protocols for human adult skin fibroblast, pancreatic stellate cells, and peritoneal fibroblasts
by: Supriya Sharma, et al.
Published: (2021-01-01)

Deciphering Transcriptomic and Metabolomic Wood Responses to Grapevine Trunk Disease-Associated Fungi
by: Ana Romeo-Oliván, et al.
Published: (2024-12-01)

CardioAtlas: deciphering the single-cell transcriptome landscape in cardiovascular tissues and diseases
by: Tiantongfei Jiang, et al.
Published: (2024-11-01)

Transcriptomic signatures of cold acclimated adipocytes reveal CXCL12 as a Brown autocrine and paracrine chemokine
by: Marina Agueda-Oyarzabal, et al.
Published: (2025-03-01)

Distinct Murine Pancreatic Transcriptomic Signatures during Chronic Pancreatitis Recovery
by: Yinjie Zhang, et al.
Published: (2021-01-01)

Deciphering Nitrogen Stress Responses in Maize Rhizospheres: Comparative Transcriptomics of Monocropping and Intercropping Systems
by: Bing Zhang, et al.
Published: (2024-10-01)