Enhancing titers of therapeutic lentiviral vectors using PKC agonists

Enhancing titers of therapeutic lentiviral vectors using PKC agonists

Lentiviral vector (LV)-based therapies employ the molecular machinery of HIV-1 to stably integrate therapeutic genes into patient cells for long-term disease correction. However, suboptimal expression of LV components in HEK293T-based production systems can limit titers and hinder clinical product d...

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Bibliographic Details
Main Authors: Charles Moore-Kelly, Rajesh Reddem, Ben M. Alberts, Jordan Wright, Thomas Evans, Anurag Kulkarni, Nicholas G. Clarkson, Daniel C. Farley, Kyriacos A. Mitrophanous, Rui André Saraiva Raposo
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
lentiviral vector
LV manufacturing
protein kinase C
PKC
PKC agonist
bioprocessing
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050125000798
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