Clinical characteristics and risk factors for mortality in Candida auris infections
Abstract Background Candida auris infections pose a threat to public health, necessitating increased awareness in China. This study aimed to analyze the strains of C. auris, assess the infection status, and investigate clinical characteristics and risk factors for mortality. Methods A retrospective...
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| Format: | Article |
| Language: | English |
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Wiley
2024-06-01
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| Series: | iLabmed |
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| Online Access: | https://doi.org/10.1002/ila2.38 |
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| author | Kang Li Xin Liu Danfeng Liu Yuqi Zhi Chang Dong Pengrui Sun Yueming Dong Hongfang Pan Yuxiang Zhang Hong Lei |
| author_facet | Kang Li Xin Liu Danfeng Liu Yuqi Zhi Chang Dong Pengrui Sun Yueming Dong Hongfang Pan Yuxiang Zhang Hong Lei |
| author_sort | Kang Li |
| collection | DOAJ |
| description | Abstract Background Candida auris infections pose a threat to public health, necessitating increased awareness in China. This study aimed to analyze the strains of C. auris, assess the infection status, and investigate clinical characteristics and risk factors for mortality. Methods A retrospective analysis was conducted on 18 patients with Candida auris infection. We focused on evaluating basic characteristics, strain sources, and antibacterial susceptibility test results. Statistical methods were used to determine clinical features and identify risk factors for death. Results The strain type, composition ratio, and specimen source of C. auris were not associated with mortality. Neither the infection index nor the length of hospitalization showed an association with the prognosis. However, significant risk factors for mortality included cerebral infarction, cardiac disease, renal dysfunction, hypoproteinemia, and anemia (all p < 0.05). Conclusions Cerebral infarction, cardiac disease, renal dysfunction, hypoproteinemia, and anemia are significant risk factors for death in C. auris infections. These findings indicate the importance of recognizing and addressing these factors in the clinical management of C. auris infection. |
| format | Article |
| id | doaj-art-41bb726e9b6c49fba0abcbe3d7210a40 |
| institution | Kabale University |
| issn | 2834-443X 2834-4448 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | iLabmed |
| spelling | doaj-art-41bb726e9b6c49fba0abcbe3d7210a402025-08-20T03:40:13ZengWileyiLabmed2834-443X2834-44482024-06-0122798710.1002/ila2.38Clinical characteristics and risk factors for mortality in Candida auris infectionsKang Li0Xin Liu1Danfeng Liu2Yuqi Zhi3Chang Dong4Pengrui Sun5Yueming Dong6Hongfang Pan7Yuxiang Zhang8Hong Lei9Laboratory Medicine Center The Eighth Medical Center of Chinese PLA General Hospital Beijing ChinaLaboratory Medicine Center The Eighth Medical Center of Chinese PLA General Hospital Beijing ChinaLaboratory Medicine Center The Eighth Medical Center of Chinese PLA General Hospital Beijing ChinaLingyuan Central Hospital Lingyuan Liaoning ChinaLaboratory Medicine Center The Eighth Medical Center of Chinese PLA General Hospital Beijing ChinaLaboratory Medicine Center The Eighth Medical Center of Chinese PLA General Hospital Beijing ChinaLaboratory Medicine Center The Eighth Medical Center of Chinese PLA General Hospital Beijing ChinaLaboratory Medicine Center The Eighth Medical Center of Chinese PLA General Hospital Beijing ChinaDepartment of Critical Care Medicine The Eighth Medical Center of Chinese PLA General Hospital Beijing ChinaLaboratory Medicine Center The Eighth Medical Center of Chinese PLA General Hospital Beijing ChinaAbstract Background Candida auris infections pose a threat to public health, necessitating increased awareness in China. This study aimed to analyze the strains of C. auris, assess the infection status, and investigate clinical characteristics and risk factors for mortality. Methods A retrospective analysis was conducted on 18 patients with Candida auris infection. We focused on evaluating basic characteristics, strain sources, and antibacterial susceptibility test results. Statistical methods were used to determine clinical features and identify risk factors for death. Results The strain type, composition ratio, and specimen source of C. auris were not associated with mortality. Neither the infection index nor the length of hospitalization showed an association with the prognosis. However, significant risk factors for mortality included cerebral infarction, cardiac disease, renal dysfunction, hypoproteinemia, and anemia (all p < 0.05). Conclusions Cerebral infarction, cardiac disease, renal dysfunction, hypoproteinemia, and anemia are significant risk factors for death in C. auris infections. These findings indicate the importance of recognizing and addressing these factors in the clinical management of C. auris infection.https://doi.org/10.1002/ila2.38Candida aurisclinical characteristicantimicrobial susceptibility testrisk factor |
| spellingShingle | Kang Li Xin Liu Danfeng Liu Yuqi Zhi Chang Dong Pengrui Sun Yueming Dong Hongfang Pan Yuxiang Zhang Hong Lei Clinical characteristics and risk factors for mortality in Candida auris infections iLabmed Candida auris clinical characteristic antimicrobial susceptibility test risk factor |
| title | Clinical characteristics and risk factors for mortality in Candida auris infections |
| title_full | Clinical characteristics and risk factors for mortality in Candida auris infections |
| title_fullStr | Clinical characteristics and risk factors for mortality in Candida auris infections |
| title_full_unstemmed | Clinical characteristics and risk factors for mortality in Candida auris infections |
| title_short | Clinical characteristics and risk factors for mortality in Candida auris infections |
| title_sort | clinical characteristics and risk factors for mortality in candida auris infections |
| topic | Candida auris clinical characteristic antimicrobial susceptibility test risk factor |
| url | https://doi.org/10.1002/ila2.38 |
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