MicroRNA governs bistable cell differentiation and lineage segregation via a noncanonical feedback

MicroRNA governs bistable cell differentiation and lineage segregation via a noncanonical feedback

Abstract Positive feedback driven by transcriptional regulation has long been considered a key mechanism underlying cell lineage segregation during embryogenesis. Using the developing spinal cord as a paradigm, we found that canonical, transcription‐driven feedback cannot explain robust lineage segr...

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Bibliographic Details
Main Authors: Chung‐Jung Li, Ee Shan Liau, Yi‐Han Lee, Yang‐Zhe Huang, Ziyi Liu, Andrew Willems, Victoria Garside, Edwina McGlinn, Jun‐An Chen, Tian Hong
Format: Article
Language:English
Published: Springer Nature 2021-04-01
Series:Molecular Systems Biology
Subjects:
motor neuron differentiation
positive feedback loop
post‐transcriptional regulation
single‐cell RNA sequencing
tissue boundary formation
Online Access:https://doi.org/10.15252/msb.20209945
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https://doi.org/10.15252/msb.20209945

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