Dopaminergic signaling to ventral striatum neurons initiates sniffing behavior
Abstract Sniffing is a motivated behavior displayed by nearly all terrestrial vertebrates. While sniffing is associated with acquiring and processing odors, sniffing is also intertwined with affective and motivated states. The systems which influence the display of sniffing are unclear. Here, we rep...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-55644-6 |
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| author | Natalie L. Johnson Anamaria Cotelo-Larrea Lucas A. Stetzik Umit M. Akkaya Zihao Zhang Marie A. Gadziola Adrienn G. Varga Minghong Ma Daniel W. Wesson |
| author_facet | Natalie L. Johnson Anamaria Cotelo-Larrea Lucas A. Stetzik Umit M. Akkaya Zihao Zhang Marie A. Gadziola Adrienn G. Varga Minghong Ma Daniel W. Wesson |
| author_sort | Natalie L. Johnson |
| collection | DOAJ |
| description | Abstract Sniffing is a motivated behavior displayed by nearly all terrestrial vertebrates. While sniffing is associated with acquiring and processing odors, sniffing is also intertwined with affective and motivated states. The systems which influence the display of sniffing are unclear. Here, we report that dopamine release into the ventral striatum in mice is coupled with bouts of sniffing and that stimulation of dopaminergic terminals in these regions drives increases in respiratory rate to initiate sniffing whereas inhibition of these terminals reduces respiratory rate. Both the firing of individual neurons and the activity of post-synaptic D1 and D2 dopamine receptor-expressing neurons are coupled with sniffing and local antagonism of D1 and D2 receptors squelches sniffing. Together, these results support a model whereby sniffing can be initiated by dopamine’s actions upon ventral striatum neurons. The nature of sniffing being integral to both olfaction and motivated behaviors implicates this circuit in a wide array of functions. |
| format | Article |
| id | doaj-art-417acd8bd9ea4883b677b8e7584fac1f |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-417acd8bd9ea4883b677b8e7584fac1f2025-01-05T12:38:10ZengNature PortfolioNature Communications2041-17232025-01-0116112310.1038/s41467-024-55644-6Dopaminergic signaling to ventral striatum neurons initiates sniffing behaviorNatalie L. Johnson0Anamaria Cotelo-Larrea1Lucas A. Stetzik2Umit M. Akkaya3Zihao Zhang4Marie A. Gadziola5Adrienn G. Varga6Minghong Ma7Daniel W. Wesson8Department of Pharmacology and Therapeutics, Florida Chemical Senses Institute, Center for Addiction Research and Education; University of Florida College of MedicineDepartment of Pharmacology and Therapeutics, Florida Chemical Senses Institute, Center for Addiction Research and Education; University of Florida College of MedicineDepartment of Pharmacology and Therapeutics, Florida Chemical Senses Institute, Center for Addiction Research and Education; University of Florida College of MedicineDepartment of Computer Engineering, Gebze Technical UniversityDepartment of Pharmacology and Therapeutics, Florida Chemical Senses Institute, Center for Addiction Research and Education; University of Florida College of MedicineDepartment of Psychology, University of Toronto ScarboroughDepartment of Neuroscience, Breathing Research and Therapeutics Center, McKnight Brain Institute; University of Florida College of MedicineDepartment of Neuroscience, Perelman School of Medicine, University of PennsylvaniaDepartment of Pharmacology and Therapeutics, Florida Chemical Senses Institute, Center for Addiction Research and Education; University of Florida College of MedicineAbstract Sniffing is a motivated behavior displayed by nearly all terrestrial vertebrates. While sniffing is associated with acquiring and processing odors, sniffing is also intertwined with affective and motivated states. The systems which influence the display of sniffing are unclear. Here, we report that dopamine release into the ventral striatum in mice is coupled with bouts of sniffing and that stimulation of dopaminergic terminals in these regions drives increases in respiratory rate to initiate sniffing whereas inhibition of these terminals reduces respiratory rate. Both the firing of individual neurons and the activity of post-synaptic D1 and D2 dopamine receptor-expressing neurons are coupled with sniffing and local antagonism of D1 and D2 receptors squelches sniffing. Together, these results support a model whereby sniffing can be initiated by dopamine’s actions upon ventral striatum neurons. The nature of sniffing being integral to both olfaction and motivated behaviors implicates this circuit in a wide array of functions.https://doi.org/10.1038/s41467-024-55644-6 |
| spellingShingle | Natalie L. Johnson Anamaria Cotelo-Larrea Lucas A. Stetzik Umit M. Akkaya Zihao Zhang Marie A. Gadziola Adrienn G. Varga Minghong Ma Daniel W. Wesson Dopaminergic signaling to ventral striatum neurons initiates sniffing behavior Nature Communications |
| title | Dopaminergic signaling to ventral striatum neurons initiates sniffing behavior |
| title_full | Dopaminergic signaling to ventral striatum neurons initiates sniffing behavior |
| title_fullStr | Dopaminergic signaling to ventral striatum neurons initiates sniffing behavior |
| title_full_unstemmed | Dopaminergic signaling to ventral striatum neurons initiates sniffing behavior |
| title_short | Dopaminergic signaling to ventral striatum neurons initiates sniffing behavior |
| title_sort | dopaminergic signaling to ventral striatum neurons initiates sniffing behavior |
| url | https://doi.org/10.1038/s41467-024-55644-6 |
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