Investigation on regulation of N-acetyltransferase 2 expression by nuclear receptors in human hepatocytes

Investigation on regulation of N-acetyltransferase 2 expression by nuclear receptors in human hepatocytes

IntroductionArylamine N-acetyltransferase 2 (NAT2) expresses a well-defined genetic polymorphism in humans that modifies drug and xenobiotic metabolism. Recent studies and genome wide association studies have reported that genetic variants of NAT2 are associated with differential risks of developing...

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Bibliographic Details
Main Authors:	Kyung U. Hong, Anthony P. Aureliano, Kennedy M. Walls, David W. Hein
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-11-01
Series:	Frontiers in Pharmacology
Subjects:	N-acetyltransferase 2 NAT2 hepatocytes nuclear receptors FXR PPARα
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1488367/full
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