Determination of antioxidant and immune responses with bile acids supplementation in geese
This study investigated the impact of varying levels of bile acids (BAs) on the immune and antioxidant functions in the geese. A total of 168 male Hortobágyi geese, aged 28 days, were randomly assigned to four groups: the control group received a basic diet, while the other groups received diets sup...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Kafkas University, Faculty of Veterinary Medicine
2024-12-01
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| Series: | Kafkas Universitesi Veteriner Fakültesi Dergisi |
| Subjects: | |
| Online Access: | https://vetdergikafkas.org/pdf.php?id=3164 |
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| Summary: | This study investigated the impact of varying levels of bile acids (BAs) on the immune and
antioxidant functions in the geese. A total of 168 male Hortobágyi geese, aged 28 days,
were randomly assigned to four groups: the control group received a basic diet, while
the other groups received diets supplemented with 75 mg/kg, 150 mg/kg, and 300 mg/
kg of BAs. The trial lasted for 35 days, after which samples were collected for the analysis
of antioxidant and immune indicators. Results showed that, compared to the control
group, the supplementation of BAs in the feed did not significantly affect the indices of
immune organs or serum immune levels (P>0.05). However, a supplementation with
300 mg/kg BAs significantly increased the expression of IL-10 mRNA in the geese"s
spleens. Regarding antioxidant indicators, the addition of 150 mg/kg and 300 mg/kg BAs
significantly enhanced the serum levels of Superoxide Dismutase (SOD), Glutathione
Peroxidase (GSH-Px), and Total Antioxidant Capacity (T-AOC) (P<0.05), as well as
upregulated the expression of liver Nrf2, GPX-1 and SOD1 mRNA. In conclusion, within
the range of BAs supplementation used in this experiment, the improvement in geese"s
immune status was limited. Although higher levels of BAs might influence the immune
status, the supplementation significantly enhanced the antioxidant capacity in serum
and liver, with an optimal addition level of 150 mg/kg. |
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| ISSN: | 1309-2251 |