Hsp90 C-terminal domain inhibition enhances ferroptosis by disrupting GPX4-VDAC1 interaction to increase HMOX1 release from oligomerized VDAC1 channels

Hsp90 C-terminal domain inhibition enhances ferroptosis by disrupting GPX4-VDAC1 interaction to increase HMOX1 release from oligomerized VDAC1 channels

Hepatocellular carcinoma (HCC) is one of the most common and lethal malignancies worldwide. Given the critical role of liver in iron storage and metabolism, ferroptosis, characterized by iron-dependent lipid peroxidation and oxidative damage, has become a potential therapy for HCC. Recent research i...

Full description

Saved in:
Bibliographic Details
Main Authors: Jieyou Li, Guibing Wu, Hairou Su, Manfeng Liang, Shengpei Cen, Yandan Liao, Xiangjun Zhou, Guantai Xie, Zihao Deng, Wenchong Tan, Yan Li, Wang Xiao, Lixia Liu, Jinxin Zhang, Zhenming Zheng, Yaotang Deng, Yaling Huang, Xiongjie Shi, Yilin Liu, Guowei Zhang, Xuemei Chen
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Redox Biology
Subjects:
Ferroptosis
Hsp90α C-terminal domain
VDAC1
Carbonylation
HMOX1
GPX4
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725001855
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://www.sciencedirect.com/science/article/pii/S2213231725001855

Similar Items