Discovery and early validation of serum protein signatures in untreated multiple sclerosis patients: identification of candidate biomarkers for diagnosis and stratification

Discovery and early validation of serum protein signatures in untreated multiple sclerosis patients: identification of candidate biomarkers for diagnosis and stratification

BackgroundDespite progress in serum biomarker research, reliable tools for early diagnosis and patient stratification in multiple sclerosis (MS) remain limited. This study uses proteomic profiling in untreated MS patients to identify early disease-associated biomarkers.MethodsWe conducted an unbiase...

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Main Authors: Isabel Brichette-Mieg, Ana Alonso-Torres, Pablo Aliaga-Gaspar, José-Luis Rodríguez-Bada, Virginia Reyes-Garrido, Patricia Urbaneja-Romero, Carmen Muñoz, María Díaz-Sánchez, Elisa Martín-Montañez, María-del-Rosario Cabello-Porras, Begoña Oliver-Martos, Laura Leyva
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
multiple sclerosis
serum biomarkers
proteomics
differentially abundant proteins
neuroinflammation
innate immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1579045/full
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