Synthesis and Characterization of Novel Ruthenium(III) Complexes with Histamine
Novel ruthenium(III) complexes with histamine [RuCl4(dmso-S)(histamineH)]⋅O (1a) and [RuCl4(dmso-S)(histamineH)] (1b) have been prepared and characterized by X-ray structure analysis. Their crystal structures are similar and show a protonated amino group on the side chain of the ligand which is not...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2010/183097 |
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| author | Jakob Kljun Saša Petriček Dušan Žigon Rosana Hudej Damijan Miklavčič Iztok Turel |
| author_facet | Jakob Kljun Saša Petriček Dušan Žigon Rosana Hudej Damijan Miklavčič Iztok Turel |
| author_sort | Jakob Kljun |
| collection | DOAJ |
| description | Novel ruthenium(III) complexes with histamine [RuCl4(dmso-S)(histamineH)]⋅O (1a) and [RuCl4(dmso-S)(histamineH)] (1b) have been prepared and characterized by X-ray structure analysis. Their crystal structures are similar and show a protonated amino group on the side chain of the ligand which is not very common for a simple heterocyclic derivative such as histamine. Biological assays to test the cytotoxicity of the compound 1b combined with electroporation were performed to determine its potential for future medical applications in cancer treatment. |
| format | Article |
| id | doaj-art-40ef7bee50ea403983cba1ec7d80c8f3 |
| institution | Kabale University |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-40ef7bee50ea403983cba1ec7d80c8f32025-08-20T03:55:35ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2010-01-01201010.1155/2010/183097183097Synthesis and Characterization of Novel Ruthenium(III) Complexes with HistamineJakob Kljun0Saša Petriček1Dušan Žigon2Rosana Hudej3Damijan Miklavčič4Iztok Turel5Faculty of Chemistry and Chemical Technology, University of Ljubljana, Aškerčeva 5, 1000 Ljubljana, SloveniaFaculty of Chemistry and Chemical Technology, University of Ljubljana, Aškerčeva 5, 1000 Ljubljana, SloveniaDepartment of Environmental Sciences, Jožef Stefan Institute, Jamova c. 39, 1000 Ljubljana, SloveniaFaculty of Chemistry and Chemical Technology, University of Ljubljana, Aškerčeva 5, 1000 Ljubljana, SloveniaFaculty of Electrical Engeneering, University of Ljubljana, Tržaška 25, 1000 Ljubljana, SloveniaFaculty of Chemistry and Chemical Technology, University of Ljubljana, Aškerčeva 5, 1000 Ljubljana, SloveniaNovel ruthenium(III) complexes with histamine [RuCl4(dmso-S)(histamineH)]⋅O (1a) and [RuCl4(dmso-S)(histamineH)] (1b) have been prepared and characterized by X-ray structure analysis. Their crystal structures are similar and show a protonated amino group on the side chain of the ligand which is not very common for a simple heterocyclic derivative such as histamine. Biological assays to test the cytotoxicity of the compound 1b combined with electroporation were performed to determine its potential for future medical applications in cancer treatment.http://dx.doi.org/10.1155/2010/183097 |
| spellingShingle | Jakob Kljun Saša Petriček Dušan Žigon Rosana Hudej Damijan Miklavčič Iztok Turel Synthesis and Characterization of Novel Ruthenium(III) Complexes with Histamine Bioinorganic Chemistry and Applications |
| title | Synthesis and Characterization of Novel Ruthenium(III) Complexes with Histamine |
| title_full | Synthesis and Characterization of Novel Ruthenium(III) Complexes with Histamine |
| title_fullStr | Synthesis and Characterization of Novel Ruthenium(III) Complexes with Histamine |
| title_full_unstemmed | Synthesis and Characterization of Novel Ruthenium(III) Complexes with Histamine |
| title_short | Synthesis and Characterization of Novel Ruthenium(III) Complexes with Histamine |
| title_sort | synthesis and characterization of novel ruthenium iii complexes with histamine |
| url | http://dx.doi.org/10.1155/2010/183097 |
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