Galectin-3-integrin α5β1 phase separation disrupted by advanced glycation end-products impairs diabetic wound healing in rodents

Galectin-3-integrin α5β1 phase separation disrupted by advanced glycation end-products impairs diabetic wound healing in rodents

Abstract Diabetic foot ulcers are severe diabetic complications, and promoting impaired angiogenesis is essential for wound healing. Pro-angiogenic galectin-3 is elevated in diabetic serum and promotes systemic insulin resistance that may impair wound healing. However, the exact role of galectin-3 i...

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Main Authors: Zhongyu Zhang, Zhengde Zhao, Xiuyi Huang, Lifang Zhou, Xin Jiang, Haoliang Wu, Chenshu Liu, Kan Huang, Jielu Wen, Yunchong Liu, Michelle C. Miller, Zihan Zhao, Zhen He, Yuxin Wang, Siyu Liu, Lijin Huang, Lining Yuan, Renli Zeng, Zhipeng Cen, Anning Chen, Yanbo Chen, Gang Zeng, Wenzhou Liu, Xiaosi Hong, Meng Ren, Li Yan, Yang Zhang, Dongxian Guan, Xiaoyu Tian, Weikang Cai, Guihua Tai, Kevin H. Mayo, Yifa Zhou, Zilun Li, Sifan Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62320-w
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