Low-dose tamoxifen treatment reduces collagen organisation indicative of tissue stiffness in the normal breast: results from the KARISMA randomised controlled trial

Low-dose tamoxifen treatment reduces collagen organisation indicative of tissue stiffness in the normal breast: results from the KARISMA randomised controlled trial

Abstract Background Tissue stiffness, dictated by organisation of interstitial fibrillar collagens, increases breast cancer risk and contributes to cancer progression. Tamoxifen is a standard treatment for receptor-positive breast cancer and is also aproved for primary prevention. We investigated th...

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Main Authors: Sara Göransson, Pablo Hernández-Varas, Mattias Hammarström, Roxanna Hellgren, Magnus Bäcklund, Kristina Lång, Ann H. Rosendahl, Mikael Eriksson, Signe Borgquist, Staffan Strömblad, Kamila Czene, Per Hall, Marike Gabrielson
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Breast Cancer Research
Online Access:https://doi.org/10.1186/s13058-024-01919-1
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