Transcriptomics and Metabolomics Explain the Crisping Mechanisms of Broad Bean-Based Crisping Diets on Nile Tilapia (<i>Orechromis niloticus</i>)
<b>Background/Objectives:</b> To investigate the crisping mechanism of broad bean-based crisping diets on Nile Tilapia. <b>Methods:</b> Four crisping diets were designed to feed 360 fish for 90 days, and multiomics analyses were employed. <b>Results:</b> Our resul...
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2024-11-01
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| author | Xiaogang He Haoming Shu Tian Xu Minhui Yu Honglin Li Yanru Hu Jiajun Mo Chunxiang Ai |
| author_facet | Xiaogang He Haoming Shu Tian Xu Minhui Yu Honglin Li Yanru Hu Jiajun Mo Chunxiang Ai |
| author_sort | Xiaogang He |
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| description | <b>Background/Objectives:</b> To investigate the crisping mechanism of broad bean-based crisping diets on Nile Tilapia. <b>Methods:</b> Four crisping diets were designed to feed 360 fish for 90 days, and multiomics analyses were employed. <b>Results:</b> Our results indicated that the designed crisping diets for Nile tilapia can effectively make tilapia muscle crispy. The ingestion of broad bean-based diets induced metabolic reprogramming dominated by glycolytic metabolism inhibition in fish, and metabolic reprogramming is the initiator of muscle structural remodeling. Among these, glucose is the main DAMP to be recognized by cellular PRRs, activating further immune response and oxidative stress and finally resulting in muscle change. <b>Conclusions:</b> Based on our results of multiomics, <i>pck2</i>, and <i>ldh</i> played main roles in crisping molecular mechanisms in driving the initial metabolic reprogram. Moreover, the addition of the crisping package further activated the ErbB signaling pathway and downstream MAPK signaling pathway to strengthen immune response, promoting muscle fiber development and growth. Our study delved into the effects of crisping formula diet on the liver of Nile tilapia at the molecular level, providing theoretical guidance for the nutritional regulation of crispy Nile tilapia. |
| format | Article |
| id | doaj-art-403d8d527adb429c80bc1e56b69f80f2 |
| institution | Kabale University |
| issn | 2218-1989 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
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| series | Metabolites |
| spelling | doaj-art-403d8d527adb429c80bc1e56b69f80f22024-11-26T18:13:10ZengMDPI AGMetabolites2218-19892024-11-01141161610.3390/metabo14110616Transcriptomics and Metabolomics Explain the Crisping Mechanisms of Broad Bean-Based Crisping Diets on Nile Tilapia (<i>Orechromis niloticus</i>)Xiaogang He0Haoming Shu1Tian Xu2Minhui Yu3Honglin Li4Yanru Hu5Jiajun Mo6Chunxiang Ai7College of Ocean & Earth Sciences, Xiamen University, Fujian 361005, ChinaCollege of Ocean & Earth Sciences, Xiamen University, Fujian 361005, ChinaMarine and Fishery Institute of Xiamen, Fujian 361000, ChinaCollege of Ocean & Earth Sciences, Xiamen University, Fujian 361005, ChinaCollege of Ocean & Earth Sciences, Xiamen University, Fujian 361005, ChinaAnyou Biotechnology Group Co., Ltd., Jiangshu 215400, ChinaAnyou Biotechnology Group Co., Ltd., Jiangshu 215400, ChinaCollege of Ocean & Earth Sciences, Xiamen University, Fujian 361005, China<b>Background/Objectives:</b> To investigate the crisping mechanism of broad bean-based crisping diets on Nile Tilapia. <b>Methods:</b> Four crisping diets were designed to feed 360 fish for 90 days, and multiomics analyses were employed. <b>Results:</b> Our results indicated that the designed crisping diets for Nile tilapia can effectively make tilapia muscle crispy. The ingestion of broad bean-based diets induced metabolic reprogramming dominated by glycolytic metabolism inhibition in fish, and metabolic reprogramming is the initiator of muscle structural remodeling. Among these, glucose is the main DAMP to be recognized by cellular PRRs, activating further immune response and oxidative stress and finally resulting in muscle change. <b>Conclusions:</b> Based on our results of multiomics, <i>pck2</i>, and <i>ldh</i> played main roles in crisping molecular mechanisms in driving the initial metabolic reprogram. Moreover, the addition of the crisping package further activated the ErbB signaling pathway and downstream MAPK signaling pathway to strengthen immune response, promoting muscle fiber development and growth. Our study delved into the effects of crisping formula diet on the liver of Nile tilapia at the molecular level, providing theoretical guidance for the nutritional regulation of crispy Nile tilapia.https://www.mdpi.com/2218-1989/14/11/616broad beancrisping dietNile tilapiametabolism reprogrammingglucose metabolism |
| spellingShingle | Xiaogang He Haoming Shu Tian Xu Minhui Yu Honglin Li Yanru Hu Jiajun Mo Chunxiang Ai Transcriptomics and Metabolomics Explain the Crisping Mechanisms of Broad Bean-Based Crisping Diets on Nile Tilapia (<i>Orechromis niloticus</i>) Metabolites broad bean crisping diet Nile tilapia metabolism reprogramming glucose metabolism |
| title | Transcriptomics and Metabolomics Explain the Crisping Mechanisms of Broad Bean-Based Crisping Diets on Nile Tilapia (<i>Orechromis niloticus</i>) |
| title_full | Transcriptomics and Metabolomics Explain the Crisping Mechanisms of Broad Bean-Based Crisping Diets on Nile Tilapia (<i>Orechromis niloticus</i>) |
| title_fullStr | Transcriptomics and Metabolomics Explain the Crisping Mechanisms of Broad Bean-Based Crisping Diets on Nile Tilapia (<i>Orechromis niloticus</i>) |
| title_full_unstemmed | Transcriptomics and Metabolomics Explain the Crisping Mechanisms of Broad Bean-Based Crisping Diets on Nile Tilapia (<i>Orechromis niloticus</i>) |
| title_short | Transcriptomics and Metabolomics Explain the Crisping Mechanisms of Broad Bean-Based Crisping Diets on Nile Tilapia (<i>Orechromis niloticus</i>) |
| title_sort | transcriptomics and metabolomics explain the crisping mechanisms of broad bean based crisping diets on nile tilapia i orechromis niloticus i |
| topic | broad bean crisping diet Nile tilapia metabolism reprogramming glucose metabolism |
| url | https://www.mdpi.com/2218-1989/14/11/616 |
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