Organobase catalyzed synthesis of pyranopyrazoles with X-ray crystallography, docking and ADME studies

Organobase catalyzed synthesis of pyranopyrazoles with X-ray crystallography, docking and ADME studies

An organobase assisted approach is adopted to synthesize pyranopyrazole derivatives in one pot. Three-component condensation reaction of 3-methylpyrazolin-5-ones, aromatic aldehydes and malononitrile were catalyzed by 5 mol% of 4-dimethylaminopyridine (DMAP) in ethanol at room temperature. Key aspec...

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Bibliographic Details
Main Authors:	Md. Musawwer Khan, Bhoomika Singh, Anam Arif, Saigal, Subash C. Sahoo
Format:	Article
Language:	English
Published:	Elsevier 2024-12-01
Series:	Tetrahedron Green Chem
Subjects:	Heterocycles Pyranopyrazoles DMAP Docking studies ADME
Online Access:	http://www.sciencedirect.com/science/article/pii/S2773223124000153
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