COMPARISON OF HEMODYNAMIC EFFECTS OF INHALATORY ILOPROST AND NITRIC OXIDE IN PATIENTS WITH SEVERE LEFT VENTRICLE DYSFUNCTION
Aim. To compare the effect of nitric oxide (NO) and inhalatory iloprost (IIP) on the hemodynamics of pulmonary hypertension patients, associated with severe systolic dysfunction of the left ventricle (LV).Material and methods. A retrospective description research performed, of the results of 158 con...
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
«FIRMA «SILICEA» LLC
2017-12-01
|
| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/1292 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849249931720654848 |
|---|---|
| author | A. E. Bautin A. S. Yakovlev S. V. Zayashnikov D. M. Tashkhanov A. O. Marichev P. A. Fedotov M. А. Bortsova Yu. V. Sazonova I. V. Sukhova I. E. Titova M. A. Simonenko M. Yu. Sitnikova V. K. Novikov O. M. Moiseeva |
| author_facet | A. E. Bautin A. S. Yakovlev S. V. Zayashnikov D. M. Tashkhanov A. O. Marichev P. A. Fedotov M. А. Bortsova Yu. V. Sazonova I. V. Sukhova I. E. Titova M. A. Simonenko M. Yu. Sitnikova V. K. Novikov O. M. Moiseeva |
| author_sort | A. E. Bautin |
| collection | DOAJ |
| description | Aim. To compare the effect of nitric oxide (NO) and inhalatory iloprost (IIP) on the hemodynamics of pulmonary hypertension patients, associated with severe systolic dysfunction of the left ventricle (LV).Material and methods. A retrospective description research performed, of the results of 158 consequently done tests for reversibility of pulmonary hypertension with NO and IIP in 124 candidates for cardiac transplantation, with pulmonary vascular resistance (PVR) more than 2,5 units of Wood. Totally, 32 females and 92 males investigated (mean age 48,9±11,2 y. o.) with heart failure (HF) of ischemic (n=59) and non-coronary (n=65) origin, with the LF ejection fraction 22,5±5,2%. Inhalation of NO in 80 ppm concentration was applied in 47 cases (39 patients), IIP with dosage 20 mcg — in 111 cases (93 patients). Pressure measurement in pulmonary artery (PA) and hemodynamics parameters was done with Swan-Ganz catheter. The data presented as the mean ± standard deviation.Results. Decrease of the mean pressure in PA was noted: at NO from 34,7±8,4 to 32,7±9,7 mmHg (p=0,015), IIP from 36,7±10 to 31,1±9,2 mmHg (p<0,001). Pulmonary resistance decreased at NO from 4,8±1,7 to 3,6±1,6 Wood units (p<0,001) and IIP — from 4,9±2 to 3,1±1,4 Wood units (p<0,001). With NO, total peripheral vascular resistance (TPVR) and blood pressure (BP) did not change, but IIP decreased TPVR from 1772±495 to 1445±444 dyn·sec·cm-5 (p<0,001) and BPav from 79,7±10 to 74,8±11,5 mmHg (p<0,001). NO caused mild overload on the LV: PA wedge pressure increased from 19,6±6,5 to 21,2±7,9 mmHg (p=0,038), contrary, IIP decreased wedge pressure from 20,2±6,5 to 18,7±6,6 mmHg (p<0,001). Increase of preand postload at NO inhalation led to decrease of the stroke volume index (SVI) from 23,8±7,9 to 22,4±6,3 mL/m2 (p=0,023). And IIP increased SVI from 26,2±7,2 to 30,7±8,7 mL/m2 (p<0,001).Conclusion. In patients with severe systolic dysfunction of the LV, IIP (contrary to NO) positively influenced the injured LV. |
| format | Article |
| id | doaj-art-3facb788f3f446988d639d2a82430fc7 |
| institution | Kabale University |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2017-12-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-3facb788f3f446988d639d2a82430fc72025-08-20T03:57:26Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202017-12-010129710310.15829/1560-4071-2017-12-97-1032071COMPARISON OF HEMODYNAMIC EFFECTS OF INHALATORY ILOPROST AND NITRIC OXIDE IN PATIENTS WITH SEVERE LEFT VENTRICLE DYSFUNCTIONA. E. Bautin0A. S. Yakovlev1S. V. Zayashnikov2D. M. Tashkhanov3A. O. Marichev4P. A. Fedotov5M. А. Bortsova6Yu. V. Sazonova7I. V. Sukhova8I. E. Titova9M. A. Simonenko10M. Yu. Sitnikova11V. K. Novikov12O. M. Moiseeva13Federal Almazov North-West Medical Research Centre of the Ministry of HealthFederal Almazov North-West Medical Research Centre of the Ministry of HealthFederal Almazov North-West Medical Research Centre of the Ministry of HealthFederal Almazov North-West Medical Research Centre of the Ministry of HealthFederal Almazov North-West Medical Research Centre of the Ministry of HealthFederal Almazov North-West Medical Research Centre of the Ministry of HealthFederal Almazov North-West Medical Research Centre of the Ministry of HealthFederal Almazov North-West Medical Research Centre of the Ministry of HealthFederal Almazov North-West Medical Research Centre of the Ministry of HealthFederal Almazov North-West Medical Research Centre of the Ministry of HealthFederal Almazov North-West Medical Research Centre of the Ministry of HealthFederal Almazov North-West Medical Research Centre of the Ministry of HealthFederal Almazov North-West Medical Research Centre of the Ministry of HealthFederal Almazov North-West Medical Research Centre of the Ministry of HealthAim. To compare the effect of nitric oxide (NO) and inhalatory iloprost (IIP) on the hemodynamics of pulmonary hypertension patients, associated with severe systolic dysfunction of the left ventricle (LV).Material and methods. A retrospective description research performed, of the results of 158 consequently done tests for reversibility of pulmonary hypertension with NO and IIP in 124 candidates for cardiac transplantation, with pulmonary vascular resistance (PVR) more than 2,5 units of Wood. Totally, 32 females and 92 males investigated (mean age 48,9±11,2 y. o.) with heart failure (HF) of ischemic (n=59) and non-coronary (n=65) origin, with the LF ejection fraction 22,5±5,2%. Inhalation of NO in 80 ppm concentration was applied in 47 cases (39 patients), IIP with dosage 20 mcg — in 111 cases (93 patients). Pressure measurement in pulmonary artery (PA) and hemodynamics parameters was done with Swan-Ganz catheter. The data presented as the mean ± standard deviation.Results. Decrease of the mean pressure in PA was noted: at NO from 34,7±8,4 to 32,7±9,7 mmHg (p=0,015), IIP from 36,7±10 to 31,1±9,2 mmHg (p<0,001). Pulmonary resistance decreased at NO from 4,8±1,7 to 3,6±1,6 Wood units (p<0,001) and IIP — from 4,9±2 to 3,1±1,4 Wood units (p<0,001). With NO, total peripheral vascular resistance (TPVR) and blood pressure (BP) did not change, but IIP decreased TPVR from 1772±495 to 1445±444 dyn·sec·cm-5 (p<0,001) and BPav from 79,7±10 to 74,8±11,5 mmHg (p<0,001). NO caused mild overload on the LV: PA wedge pressure increased from 19,6±6,5 to 21,2±7,9 mmHg (p=0,038), contrary, IIP decreased wedge pressure from 20,2±6,5 to 18,7±6,6 mmHg (p<0,001). Increase of preand postload at NO inhalation led to decrease of the stroke volume index (SVI) from 23,8±7,9 to 22,4±6,3 mL/m2 (p=0,023). And IIP increased SVI from 26,2±7,2 to 30,7±8,7 mL/m2 (p<0,001).Conclusion. In patients with severe systolic dysfunction of the LV, IIP (contrary to NO) positively influenced the injured LV.https://russjcardiol.elpub.ru/jour/article/view/1292pulmonary hypertensioniloprostnitric oxideheart failure |
| spellingShingle | A. E. Bautin A. S. Yakovlev S. V. Zayashnikov D. M. Tashkhanov A. O. Marichev P. A. Fedotov M. А. Bortsova Yu. V. Sazonova I. V. Sukhova I. E. Titova M. A. Simonenko M. Yu. Sitnikova V. K. Novikov O. M. Moiseeva COMPARISON OF HEMODYNAMIC EFFECTS OF INHALATORY ILOPROST AND NITRIC OXIDE IN PATIENTS WITH SEVERE LEFT VENTRICLE DYSFUNCTION Российский кардиологический журнал pulmonary hypertension iloprost nitric oxide heart failure |
| title | COMPARISON OF HEMODYNAMIC EFFECTS OF INHALATORY ILOPROST AND NITRIC OXIDE IN PATIENTS WITH SEVERE LEFT VENTRICLE DYSFUNCTION |
| title_full | COMPARISON OF HEMODYNAMIC EFFECTS OF INHALATORY ILOPROST AND NITRIC OXIDE IN PATIENTS WITH SEVERE LEFT VENTRICLE DYSFUNCTION |
| title_fullStr | COMPARISON OF HEMODYNAMIC EFFECTS OF INHALATORY ILOPROST AND NITRIC OXIDE IN PATIENTS WITH SEVERE LEFT VENTRICLE DYSFUNCTION |
| title_full_unstemmed | COMPARISON OF HEMODYNAMIC EFFECTS OF INHALATORY ILOPROST AND NITRIC OXIDE IN PATIENTS WITH SEVERE LEFT VENTRICLE DYSFUNCTION |
| title_short | COMPARISON OF HEMODYNAMIC EFFECTS OF INHALATORY ILOPROST AND NITRIC OXIDE IN PATIENTS WITH SEVERE LEFT VENTRICLE DYSFUNCTION |
| title_sort | comparison of hemodynamic effects of inhalatory iloprost and nitric oxide in patients with severe left ventricle dysfunction |
| topic | pulmonary hypertension iloprost nitric oxide heart failure |
| url | https://russjcardiol.elpub.ru/jour/article/view/1292 |
| work_keys_str_mv | AT aebautin comparisonofhemodynamiceffectsofinhalatoryiloprostandnitricoxideinpatientswithsevereleftventricledysfunction AT asyakovlev comparisonofhemodynamiceffectsofinhalatoryiloprostandnitricoxideinpatientswithsevereleftventricledysfunction AT svzayashnikov comparisonofhemodynamiceffectsofinhalatoryiloprostandnitricoxideinpatientswithsevereleftventricledysfunction AT dmtashkhanov comparisonofhemodynamiceffectsofinhalatoryiloprostandnitricoxideinpatientswithsevereleftventricledysfunction AT aomarichev comparisonofhemodynamiceffectsofinhalatoryiloprostandnitricoxideinpatientswithsevereleftventricledysfunction AT pafedotov comparisonofhemodynamiceffectsofinhalatoryiloprostandnitricoxideinpatientswithsevereleftventricledysfunction AT mabortsova comparisonofhemodynamiceffectsofinhalatoryiloprostandnitricoxideinpatientswithsevereleftventricledysfunction AT yuvsazonova comparisonofhemodynamiceffectsofinhalatoryiloprostandnitricoxideinpatientswithsevereleftventricledysfunction AT ivsukhova comparisonofhemodynamiceffectsofinhalatoryiloprostandnitricoxideinpatientswithsevereleftventricledysfunction AT ietitova comparisonofhemodynamiceffectsofinhalatoryiloprostandnitricoxideinpatientswithsevereleftventricledysfunction AT masimonenko comparisonofhemodynamiceffectsofinhalatoryiloprostandnitricoxideinpatientswithsevereleftventricledysfunction AT myusitnikova comparisonofhemodynamiceffectsofinhalatoryiloprostandnitricoxideinpatientswithsevereleftventricledysfunction AT vknovikov comparisonofhemodynamiceffectsofinhalatoryiloprostandnitricoxideinpatientswithsevereleftventricledysfunction AT ommoiseeva comparisonofhemodynamiceffectsofinhalatoryiloprostandnitricoxideinpatientswithsevereleftventricledysfunction |