Design, synthesis and anti-cancer activity of novel 1,2,3-triazole hybrids of erlotinib against cervical cancer via MAPK signaling pathway

Design, synthesis and anti-cancer activity of novel 1,2,3-triazole hybrids of erlotinib against cervical cancer via MAPK signaling pathway

Abstract Cervical cancer, a common malignant tumor of the female reproductive system, ranks fourth in incidence and mortality among female cancers globally, which highlights the urgent need for new therapeutic agents to improve treatment outcomes. In this study, 16 new erlotinib-1,2,3-triazole deriv...

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Bibliographic Details
Main Authors: Lan Wang, Xixi Hou, Mengmeng Huang, Baoyu He, Longfei Mao, Zhengwei Hu, Ling Li, Jingjing Guo, Lizeng Peng
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Cervical cancer
Erlotinib
Triazole
Apoptosis
MAPK signaling pathway
Online Access:https://doi.org/10.1038/s41598-025-09168-8
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https://doi.org/10.1038/s41598-025-09168-8

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