Real-time genome imaging of host interactions in adeno-associated virus genome release

Real-time genome imaging of host interactions in adeno-associated virus genome release

Summary: Adeno-associated virus (AAVs) with a self-complementary genome (sc) comprising a gene of interest are used in gene therapy. Their efficiency is limited but the molecular factors contributing to this restriction are poorly understood. We utilized scAAV2 containing a fluorescent protein-bindi...

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Main Authors: Luisa F. Bustamante-Jaramillo, Lei Yue, Joshua Fingal, Gustaf Rydell, Maria Johansson, Tomas Edreira, Oliver J. Müller, Susanne Hille, Martin Müller, Franck Gallardo, Qingxin Chen, Marie-Lise Blondot, Michael Kann
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:iScience
Subjects:
Cellular therapy
Genomics
Virology
Genomic analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225008855
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http://www.sciencedirect.com/science/article/pii/S2589004225008855

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